{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:22:45Z","timestamp":1782285765295,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001257"],"award-info":[{"award-number":["82001257"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82027802"],"award-info":[{"award-number":["82027802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Object<\/jats:title><jats:p>The long\u2010term functional outcome of cerebral amyloid angiopathy\u2010related hemorrhage (CAAH) patients is unclear. We sought to assess the long\u2010term functional outcome of CAAH and determine the prognostic factors associated with unfavorable outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled consecutive CAAH patients from 2014 to 2020 in this observational study. Baseline characteristics and clinical outcomes were presented. Multivariable logistic regression analysis was performed to identify the prognostic factors associated with long\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 141 CAAH patients, 76 (53.9%) achieved favorable outcomes and 28 (19.9%) of them died at 1\u2010year follow\u2010up. For the longer\u2010term follow\u2010up with a median observation time of 19.0 (interquartile range, 12.0\u201326.5) months, 71 (50.4%) patients obtained favorable outcomes while 33 (23.4%) died. GCS on admission (OR, 0.109; 95% CI, 0.021\u20130.556;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), recurrence of ICH (OR, 2923.687; 95% CI, 6.282\u20131360730.14;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.011), WML grade 3\u20134 (OR, 31.007; 95% CI, 1.041\u2013923.573;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.047), severe central atrophy (OR, 4220.303; 95% CI, 9.135\u20131949674.84;<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) assessed by CT was identified as independent predictors for long\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Nearly 50% of CAAH patients achieved favorable outcomes at long\u2010term follow\u2010up. GCS, recurrence of ICH, WML grade and cerebral atrophy were identified as independent prognostic factors of long\u2010term outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13922","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T06:39:42Z","timestamp":1660718382000},"page":"1829-1837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term outcome of cerebral amyloid angiopathy\u2010related hemorrhage"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-7900","authenticated-orcid":false,"given":"Ruiwen","family":"Che","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine Beijing 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