{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:05:31Z","timestamp":1775790331118,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7212047"],"award-info":[{"award-number":["7212047"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purposes<\/jats:title><jats:p>Differentiating between acquired stenosis (pathologic) and anatomical slenderness (physiologic) of internal jugular vein (IJV) remain ambiguous. Herein, we aimed to compare the similarities and differences between the two entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent head and neck computer tomography (CT) and brain magnetic resonance imaging (MRI) were enrolled in this case\u2010control study from January 2016 through October 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1487 eligible patients entered final analysis totally. 803 patients had bilateral IJVs imaging without IJV stenosis\u2010related symptoms and presented in three ways: right IJV slenderness (10.5%, n\u00a0=\u00a085), left IJV slenderness (48.4%, <jats:italic>n<\/jats:italic>\u00a0=\u00a0388), and symmetric IJVs (41.1%, <jats:italic>n<\/jats:italic>\u00a0=\u00a0330). In patients with asymmetric IJVs, their bilateral jugular foramina were also asymmetric. All involved asymmetric IJVs presented as slenderness without surrounding abnormal collaterals and credible cloudy\u2010like white matter hyper\u2010intensity (WMH). Their cerebral arterial perfusion statuses on brain MR\u2010PWI maps were normal.<\/jats:p><jats:p>In contrast, the major patients with IJV stenosis presented with signs and symptoms such as headaches, head noise, etc. In CE\u2010MRV maps, local stenosis of the IJV was surrounded by abnormal venous collaterals in contrast to the lack of abnormal venous collaterals for patients with IJV slenderness. And in CTV maps, the caliber of jugular foramina was mismatched with the transverse diameter of IJV. Moreover, in MRI maps of most of these patients, a cloudy\u2010like WMHs were distributed symmetrically in bilateral periventricular and\/or centrum semi vales. These patients also had symmetrical cerebral arterial hypo\u2010perfusion. Seven patients underwent stenting of the IJV stenosis correction, their WMHs attenuated or disappeared subsequently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Imaging features in addition to clinical symptoms can be used to differentiate between physiologic IJV slenderness and pathologic IJV stenosis. Notable imagine\u2010defining features for IJV stenosis include local stenosis surrounded by abnormal venous collaterals, cloudy\u2010like WMHs, and mismatch between the transverse diameter of IJV and the caliber of the jugular foramina.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13924","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T06:38:49Z","timestamp":1659508729000},"page":"1849-1860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Differentiation between anatomical slenderness and acquired stenosis of the internal jugular veins"],"prefix":"10.1111","volume":"28","author":[{"given":"Mengqi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Advanced Center of Stroke Beijing Institute for Brain Disorders  Beijing China"},{"name":"National Center for Neurological Disorders, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Advanced Center of Stroke Beijing Institute for Brain Disorders  Beijing China"},{"name":"National Center for Neurological Disorders, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Advanced Center of Stroke Beijing Institute for Brain Disorders  Beijing China"},{"name":"National Center for Neurological Disorders, Xuanwu Hospital Capital Medical University  Beijing 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