{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:13:51Z","timestamp":1771326831878,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:00:00Z","timestamp":1659225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870905"],"award-info":[{"award-number":["81870905"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82111530203"],"award-info":[{"award-number":["82111530203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20358"],"award-info":[{"award-number":["U20A20358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Main problem<\/jats:title><jats:p>The prognostic value of soluble lectin\u2010like oxidized low\u2010density lipoproteinreceptor\u20101 (sLOX\u20101) for stroke was unclearly. This study aimed to investigate the association between sLOX\u20101 and recurrent stroke in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from the Third China National Stroke Registry. Eligible cases consisted of 400 patients who developed recurrent stroke within 1\u2010year follow\u2010up, 800 controls were selected using age\u2010 and sex\u2010matched with a 1:2 case\u2013control ratio. Conditional logistic regressions were used to evaluate the association between sLOX\u20101 and recurrent stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1200 patients included in this study, the median (interquartile range) of sLOX\u20101 was 247.12 (132.81\u2013413.58) ng\/L. After adjustment for conventional confounding factors, the odds ratio with 95% confidence interval in the highest tertile versus the lowest tertile was 2.23 (1.61\u20133.08) for recurrent stroke, 2.31 (1.64\u20133.24) for ischemic stroke, 2.30 (1.66\u20133.19) for combined vascular events within 1\u2010year follow\u2010up. Furthermore, the addition of sLOX\u20101 to a conventional risk model had an incremental effect on predictive value for recurrent stroke (C\u2010statistics 0.76, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; integrated discrimination improvement 13.38%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; net reclassification improvement 55.39%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Similar results were observed when the timepoint was set up as 3\u00a0months. Subgroup analysis showed the association between higher sLOX\u20101 and recurrent stroke was more pronounced in patients with a history of stroke (<jats:italic>p<\/jats:italic> for interaction\u00a0=\u00a00.0062).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>sLOX\u20101 was positively associated with the risk of recurrent stroke, which may be a candidate biomarker to improve risk stratification of recurrent stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13932","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T06:24:42Z","timestamp":1659335082000},"page":"2001-2010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Soluble lectin\u2010like oxidized low\u2010density Lipoproteinreceptor\u20101 and recurrent stroke: A nested case\u2013control 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University  Beijing China"},{"name":"China National 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tiantan Hospital, Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University  Beijing 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