{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:10Z","timestamp":1787014030113,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101508"],"award-info":[{"award-number":["82101508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171533"],"award-info":[{"award-number":["82171533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The present study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) and nonamnestic MCI (naMCI), which enhances the understanding of their different pathophysiologies and provides targets for individualized intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010five naMCI and 48 aMCI subjects and 75 healthy controls were recruited. A sliding window analysis was used to evaluate the dynamic amplitude of low\u2010frequency fluctuations (dALFF), dynamic regional homogeneity (dReHo), and dynamic functional connectivity (dFC). The caudal\/rostral hippocampus was selected as the seeds for calculating dFC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both aMCI and naMCI exhibited abnormal dALFF, dReHo, and hippocampal dFC compared with healthy controls. Compared with individuals with naMCI, those with aMCI exhibited (1) higher dALFF variability in the right putamen, left Rolandic operculum, and right middle cingulum, (2) lower dReHo variability in the right superior parietal lobule, and (3) lower dFC variability between the hippocampus and other regions (left superior occipital gyrus, middle frontal gyrus, inferior cerebellum, precuneus, and right superior frontal gyrus). Additionally, variability in dALFF, dReHo, and hippocampal dFC exhibited different associations with cognitive scores in aMCI and naMCI patients, respectively. Finally, dReHo variability in the right superior parietal lobule and dFC variability between the right caudal hippocampus and left inferior cerebellum exhibited partially mediated effects on the different memory scores between people with aMCI and naMCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The aMCI and naMCI patients exhibited shared and specific patterns of dynamic brain activity and connectivity. The dReHo of the superior parietal lobule and dFC of the hippocampus\u2010cerebellum contributed to the memory heterogeneity of MCI subtypes. Analyzing the temporal variability in the spontaneous fluctuations of brain activity and connectivity provided a new perspective for exploring the different pathophysiological mechanisms in MCI subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.13937","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:21:21Z","timestamp":1660706481000},"page":"2053-2065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Shared and specific dynamics of brain activity and connectivity in amnestic and nonamnestic mild cognitive impairment"],"prefix":"10.1111","volume":"28","author":[{"given":"Xiaomei","family":"Zhong","sequence":"first","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-1413","authenticated-orcid":false,"given":"Ben","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"},{"name":"Department of Geriatric Psychiatry The Second People's Hospital of Dali Bai Autonomous Prefecture  Dali Yunnan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangying","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohong","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Ning","sequence":"additional","affiliation":[{"name":"Center for Geriatric Neuroscience The Affiliated Brain Hospital of Guangzhou Medical University, Memory Clinic  Guangzhou Guangdong Province China"},{"name":"The First School of Clinical Medicine, Southern Medical University  Guangzhou Guangdong Province China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-12104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.1.59"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000294"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.916"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000252358.03285.9d"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095427"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00309"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.12.011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00052"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610212000270"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.10.016"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.625232"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.695210"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.02.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00307"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709090523"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201284"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.09.012"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.079"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2019.2904555"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2017.09.015"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40268"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.12.013"},{"key":"e_1_2_10_27_1","first-page":"747","article-title":"Shared and specific patterns of dynamic functional connectivity variability of striato\u2010cortical circuitry in unmedicated bipolar and major depressive disorders","volume":"1","author":"Chen G","year":"2020","journal-title":"Psychol Med"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.11.012"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00897"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00152"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-7214"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2019.2928790"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23711"},{"key":"e_1_2_10_34_1","volume-title":"Brain electrical activity mapping for diagnosing psychiatric disorders: a review of the clinical evidence","year":"2014"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-6177(94)90018-3"},{"key":"e_1_2_10_36_1","volume-title":"Boston naming test","author":"Kaplan EF","year":"1983"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2020.1825637"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00557"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191115602552"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acz020"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191108315611"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.115"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.01.054"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01671-0"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw157"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.550664"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.04.023"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2012.00038"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1218-6"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-017-0870-x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-03981-6"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2017.05.008"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.01.002"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20141"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9120338"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2009.11.008"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.001"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu132"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2013.01.020"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20077"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151010"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.04.011"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.047"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24235"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721004906"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720002378"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00609"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.13937","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.13937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:45:01Z","timestamp":1692675901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.13937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":68,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/cns.13937"],"URL":"https:\/\/doi.org\/10.1111\/cns.13937","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,17]]},"assertion":[{"value":"2021-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}