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However, the pathological mechanisms underlying neurodegenerative diseases are not fully understood. NG2\u2010glia abnormalities and microglia activation are involved in the development and\/or progression of neurodegenerative disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and cerebrovascular diseases. In this review, we summarize the present understanding of the interaction between NG2\u2010glia and microglia in physiological and pathological states and discuss unsolved questions concerning their fate and potential fate. First, we introduce the NG2\u2010glia and microglia in health and disease. Second, we formulate the interaction between NG2\u2010glia and microglia. NG2\u2010glia proliferation, migration, differentiation, and apoptosis are influenced by factors released from the microglia. On the other hand, NG2\u2010glia also regulate microglia actions. We conclude that NG2\u2010glia and microglia are important immunomodulatory cells in the brain. Understanding the interaction between NG2\u2010glia and microglia will help provide a novel method to modulate myelination and treat neurodegenerative disorders.<\/jats:p>","DOI":"10.1111\/cns.13948","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T06:45:12Z","timestamp":1661323512000},"page":"1663-1674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<scp>NG2<\/scp>\u2010glia crosstalk with microglia in health and disease"],"prefix":"10.1111","volume":"28","author":[{"given":"Zuo","family":"Zhang","sequence":"first","affiliation":[{"name":"National Drug Clinical Trial Institution, Second Affiliated Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Li","sequence":"additional","affiliation":[{"name":"National Drug Clinical Trial Institution, Second Affiliated Hospital Army Medical University  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