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Recent studies have reported that 3\u2010n\u2010butylphthalide (NBP) has a positive effect on improving cognitive impairment; however, its clinical efficacy and safety is unclear. Therefore, we conducted a meta\u2010analysis to assess its efficacy and safety for cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched the PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus databases, and two reviewers independently screened and extracted the data from included studies. We synthesized the data using the Review Manager Software version 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included six randomized clinical trials (RCTs), encompassing 851 patients with cognitive impairment. The results showed that NBP improved cognitive impairment. Specifically, the clinical efficacy was better than that in the control group, with better performance in improving the Mini\u2010Mental State Examination and the Montreal Cognitive Assessment scores, while decreasing the Alzheimer's Disease Assessment Scale\u2010Cognitive subscale and the Clinician's Interview\u2010Based Impression of Change plus caregiver input scores. There was no significant difference in the incidence of adverse events between both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The NBP is effective and safe in improving cognitive impairment; however, more high\u2010quality RCTs are needed to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.13952","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T08:24:32Z","timestamp":1662020672000},"page":"1706-1717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy and safety of 3\u2010n\u2010butylphthalide for the treatment of cognitive impairment: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3313-629X","authenticated-orcid":false,"given":"Qiulu","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology Union Hospital, 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