{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:00:38Z","timestamp":1792641638850,"version":"4.5.0"},"reference-count":73,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071215"],"award-info":[{"award-number":["82071215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001154"],"award-info":[{"award-number":["82001154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Hypoxic\u2013ischemic brain injury (HIBI) often results in cognitive impairments. Herein, we investigated the roles of ferroptosis in HIBI and the underlying signaling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ferrostatin\u20101 (Fer\u20101) or resveratrol (Res) treatments were administered intracerebroventricularly 30\u2009min before HIBI in 7\u2010day\u2010old rats. Glutathione peroxidase 4 (GPx4) expression, malondialdehyde (MDA) concentration, iron content, mitochondrial morphology, and the expression of silent information regulator factor 2\u2010related enzyme 1 (SIRT1) and nuclear factor erythroid\u20102\u2010related factor 2 (Nrf2) were measured after HIBI. Additionally, the weight ratio of left\/right hemisphere, brain morphology, Nissl staining, and the Morris water maze test were conducted to estimate brain damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 24\u2010h post\u2010HIBI, GPx4 expression was decreased, and MDA concentration and iron content were increased in the hippocampus. HIBI led to mitochondrial atrophy, brain atrophy\/damage, and resultant learning and memory impairments, which were alleviated by Fer\u20101\u2010mediated inhibition of ferroptosis. Furthermore, Res\u2010mediated SIRT1 upregulation increased Nrf2 and GPx4 expression, thereby attenuating ferroptosis, reducing brain atrophy\/damage, and improving learning and memory abilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results demonstrated that during HIBI, ferroptosis occurs via the SIRT1\/Nrf2\/GPx4 signaling pathway, suggesting it as a potential therapeutic target for inhibiting ferroptosis and ameliorating HIBI\u2010induced cognitive impairments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.13973","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:25:51Z","timestamp":1664756751000},"page":"2268-2280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Ferroptosis contributes to hypoxic\u2013ischemic brain injury in neonatal rats: Role of the\n                    <scp>SIRT1<\/scp>\n                    \/Nrf2\/\n                    <scp>GPx4<\/scp>\n                    signaling pathway"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-0896","authenticated-orcid":false,"given":"Chang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shengjing Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-9127","authenticated-orcid":false,"given":"Ziyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shengjing Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shengjing Hospital of China Medical University  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