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The proposed treatment method used three types of sound stimulation and air or bone conduction sound transmission methods to induce total of 6\u2010time EEG electroencephalogram(EEG) changes. EEG was measured with 200 sampling rate each in the P4, Cz, F8 and T7 channel located in the parietal, central, frontal and temporal lobes, respectively, according to the 10\/10 system. A total of 2\u00a0min of data were created by extracting EEG signals with less noise from the measured data and the extracted data were applied with a 1\u201340\u2009Hz Butterworth filter and a 50\u2009Hz notch filter with a quality factor of 30. After that, EEG are subdivided into delta (0.5\u20134\u00a0Hz), theta (4\u20138\u00a0Hz), alpha (8\u201313\u2009Hz), beta (13\u201330\u2009Hz), and gamma (30\u201345\u2009Hz) bands. Finally, EEG changes in response to sound stimuli were analyzed using power spectral density and T\u2010test validation in the frequency band.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When a sound stimulus of less than 1\u2009KHz was stimulated by air conduction, brainstem activation was induced and the reticular activation system was activated. In addition, a great potential for replacing drugs was confirmed by inducing changes in the nervous system similar to drugs used for sedation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results will be able to expand the concept of digital therapeutics, and it is expected that it will be developed as a safer treatment method that can replace surgery and drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14014","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T08:40:36Z","timestamp":1668501636000},"page":"402-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The sound stimulation method and <scp>EEG<\/scp> change analysis for development of digital therapeutics that can stimulate the nervous system: Cortical activation and drug substitution potential"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-0756","authenticated-orcid":false,"given":"Deachang","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology Dongguk University\u2010Bio Medi Campus  South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JaeHyun","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of R&amp;D Support Research Institute for Commercialization of Biomedical Convergence Technology  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeahoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Research Institute for Commercialization of Biomedical Convergence Technology Dongguk University  South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology Dongguk University\u2010Bio Medi Campus  South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35775-3.00014-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-016-1920-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12283"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.069245"},{"key":"e_1_2_10_6_1","first-page":"1453","article-title":"EEG studies of sleep in the diagnosis of depression","volume":"17","author":"Feinberg M","year":"1982","journal-title":"Biol Psychiatry"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720510792231720"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2020.2969915"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2020.3022715"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00521-017-3006-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-021-09542-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03319.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.07.029"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-019-01093-7"},{"key":"e_1_2_10_16_1","first-page":"92196","article-title":"A programmable EEG monitoring SoC with optical and electrical stimulation for epilepsy control","volume":"8","author":"Lee S\u2010Y","year":"2020","journal-title":"IEEE Access"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.1.109"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.02.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.629323"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.02.007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00744"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13172"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2019.35"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2022.2051479"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1952.02320140013002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00103"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2012.11.002"},{"key":"e_1_2_10_28_1","first-page":"180","volume-title":"Auditory evoked potentials. 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