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This study aimed to explore shared functional network abnormalities in patients with sporadic temporal lobe epilepsy and their unaffected siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight patients with sporadic temporal lobe epilepsy, 13 unaffected siblings, and 30 healthy controls participated in this cross\u2010sectional study. We examined the task\u2010based whole\u2010brain functional network topology and the effective functional connectivity between networks identified by group\u2010independent component analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed increased global efficiency, decreased clustering coefficiency, and decreased small\u2010worldness in patients and siblings (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, false discovery rate\u2010corrected). The effective network connectivity from the ventral attention network to the limbic system was impaired (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, false discovery rate\u2010corrected). These features had higher prevalence in unaffected siblings than in normal population and was not correlated with disease burden. In addition, topological abnormalities had a high intraclass correlation between patients and their siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with temporal lobe epilepsy and their unaffected siblings showed shared topological functional disturbance and the effective functional network connectivity impairment. These abnormalities may contribute to the pathogenesis that promotes the susceptibility of seizures and language decline in temporal lobe epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14087","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T12:09:09Z","timestamp":1673957349000},"page":"1109-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-3321","authenticated-orcid":false,"given":"Kangrun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha China"},{"name":"Department of Neurosurgery, Xiangya Hospital Central South University  Changsha China"},{"name":"Clinical Research Center for Epileptic disease 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