{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:49:09Z","timestamp":1792198149429,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2004701"],"award-info":[{"award-number":["2020YFC2004701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071302"],"award-info":[{"award-number":["82071302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess differences in the clinical prognosis between different treatment timings in poor\u2010grade (Hunt and Hess grade 4\u20135) aneurysmal subarachnoid hemorrhage patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The treated 127 poor\u2010grade aneurysmal subarachnoid hemorrhage patients were divided into three groups: early treatment within 2\u2009days, treatment on days 3 to 10, and treatment for more than 10\u2009days after the hemorrhage. Odd ratios with a 95% confidence interval were calculated in logistic regression for different timing strategies regarding delayed cerebral ischemia and poor prognosis at 3\u2009months. Subgroup analyses were conducted to determine whether the different timing strategies affect the prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients who received the treatment on days 3 to 10 were prone to develop delayed cerebral ischemia and poor prognosis at 3\u2009months. Postponing treatment in patients older than 55\u2009years or diagnosed with an intraventricular hematoma on the initial computed tomography scan may lead to poor prognosis, with the early intervention group as a reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early intervention in poor\u2010grade aneurysmal subarachnoid hemorrhage is suggested to be implemented. The treatment on 3 to 10\u2009days harbored the highest risk of poor prognosis; patients might benefit more from early intervention, especially for ones older than 55\u2009years or diagnosed with an intraventricular hematoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14088","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T05:25:41Z","timestamp":1673414741000},"page":"1120-1128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Timing of operation for poor\u2010grade aneurysmal subarachnoid hemorrhage: Relationship with delayed cerebral ischemia and poor prognosis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-0729","authenticated-orcid":false,"given":"Junlin","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, West China Hospital Sichuan University  Chengdu 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