{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:28:51Z","timestamp":1793305731117,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The relationship between oscillatory activity in hippocampus and cognitive impairment in traumatic brain injury (TBI) remains unclear. Although TBI decreases gamma oscillations and 40\u2009Hz light flicker improves TBI prognosis, the effects and mechanism of rhythmic flicker on TBI remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we aimed to explore whether light flicker could reverse cognitive deficits, and further explore its potential mechanisms in TBI mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Morris water maze test (MWM), step\u2010down test (SDT), and novel object recognition test (NOR) were applied to evaluate the cognitive ability. The local field potential (LFP) recording was applied to measure low gamma reduction of CA1 in hippocampus after TBI. And electrophysiological experiments were applied to explore effects of the gamma frequency entrainment on long\u2010term potentiation (LTP), postsynaptic transmission, and intrinsic excitability of CA1 pyramidal cells (PCs) in TBI mice. Immunofluorescence staining and western blotting were applied to explore the effects of 40\u2009Hz light flicker on the expression of PSD95 in hippocampus of TBI mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 40\u2009Hz light flicker restored low gamma reduction of CA1 in hippocampus after TBI. And 40\u2009Hz, but not random or 80\u2009Hz light flicker, reversed cognitive impairment after TBI in behavioral tests. Moreover, 40\u2009Hz light flicker improved N\u2010methyl\u2010D\u2010aspartate (NMDA) receptor\u2010dependent LTP (LTP<jats:sub>NMDAR<\/jats:sub>) and L\u2010type voltage\u2010gated calcium channel\u2010dependent LTP (LTP<jats:sub>L\u2010VGCC<\/jats:sub>) after TBI treatment. And gamma frequency entrainment decreased excitatory postsynaptic currents (EPSCs) of CA1 PCs in TBI mice. Our results have illustrated that 40\u2009Hz light flicker could decrease intrinsic excitability of PCs after TBI treatment in mice. Furthermore, 40\u2009Hz light flicker decreased the expression of PSD95 in hippocampus of TBI mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results demonstrated that 40\u2009Hz light flicker rescues cognitive impairment by decreasing postsynaptic transmission in PCs after TBI treatment in mice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14096","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T01:50:37Z","timestamp":1675648237000},"page":"1142-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Gamma frequency entrainment rescues cognitive impairment by decreasing postsynaptic transmission after traumatic brain injury"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7017-6541","authenticated-orcid":false,"given":"Weijie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of 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