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The membrane fluorescence and protein levels of GABA<jats:sub>B<\/jats:sub>R was also decreased in NAc GAD<jats:sub>67<\/jats:sub><jats:sup>+<\/jats:sup> neurons post cocaine (1 \u03bcM) treatment after 5 min. Moreover, the majority of internalized GABA<jats:sub>B1<\/jats:sub>Rs exhibited perinuclear localization, a decrease in GABA<jats:sub>B1<\/jats:sub>R\u2010pHluroin signals was observed in cocaine\u2010treated NAc neurons. By contrast, membrane expression of phosphorylated CaMKII (pCaMKII) post cocaine treatment was significantly increased after day 1, 3, 5 and 7. Baclofen blocked the cocaine induced behavioral sensitization via inhibition of cocaine enhanced\u2010pCaMKII\u2010GABA<jats:sub>B1<\/jats:sub>R interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings reveal a new mechanism by which pCaMKII\u2010GABA<jats:sub>B<\/jats:sub>R signaling can promote psychostimulant\u2010induced behavioral sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14107","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T07:56:33Z","timestamp":1675929393000},"page":"1345-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The <scp>CaMKII<\/scp>\u2010dependent phosphorylation of <scp>GABA<sub>B<\/sub><\/scp> receptors in the nucleus accumbens was involved in cocaine\u2010induced behavioral sensitization in rats"],"prefix":"10.1111","volume":"29","author":[{"given":"Ming F.","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, College of Basic Medicine Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology, Department of Pathology, Schools of Basic Medical Sciences and Pharmaceutical Sciences Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Respiration, Department Two Jiangxi Provincial People's Hospital  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian Y.","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, College of Basic Medicine Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology, Department of Pathology, Schools of Basic Medical Sciences and Pharmaceutical Sciences Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Basic Medicine Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing H.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital Nanchang University  Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7020-3071","authenticated-orcid":false,"given":"Zhen Z.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, College of Basic Medicine Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology, Department of Pathology, Schools of Basic Medical 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