{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:35:39Z","timestamp":1783665339527,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate changes in brain\u2010glucose metabolism in anti\u2010N\u2010methyl\u2010D\u2010aspartate receptor (NMDAR) encephalitis, and compare results with MRI and electroencephalography (EEG) findings at different disease stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of 18 patients (median age, 35\u2009years; 11 men) were retrospectively collected. Patients were divided into groups based on the time of symptom onset to examination, (\u22641\u00a0month, &gt;1 but \u22643\u00a0months, &gt;3\u00a0months). Two\u2010sample<jats:italic>t<\/jats:italic>\u2010test results were compared with age and sex\u2010paired healthy controls using statistical parametric mapping and verified using a NeuroQ software normal database with a discriminating z\u2010score of 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal patterns on FDG\u2010PET differed over time (<jats:italic>T<\/jats:italic>\u00a0=\u00a03.21\u20138.74,<jats:italic>Z<\/jats:italic>\u00a0=\u00a02.68\u20134.23,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005). Regional analysis showed hypometabolic left middle or medial frontal cortex in 4\/5, 5\/7, and 5\/6 patients, respectively. Time\u2010subgroup analysis revealed hypermetabolic supertemporal cortex in 4\/5, 5\/7, and 2\/6, patients, respectively. MRI and EEG abnormalities in any region and stage occurred in 10\/18 and 10\/16 patients, respectively. MRI and EEG time\u2010subgroup analysis showed abnormalities in 5\/9, 4\/5, and 1\/4, and 1\/3, 6\/7, and 3\/6 patients, respectively. Abnormal temporal lobes were detected most frequently in MRI analyses and occurred in 3\/10 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Decreased left middle\/medial frontal metabolism could be common to all stages. Metabolism in other regions, MRI, and EEG results were associated with the progression of anti\u2010NMDAR encephalitis. The sensitivity rate of FDG\u2010PET was superior to that of MRI and EEG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14125","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T08:39:27Z","timestamp":1677141567000},"page":"1624-1635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypometabolism of the left middle\/medial frontal lobe on<scp>FDG\u2010PET<\/scp>in anti\u2013<scp>NMDA<\/scp>receptor encephalitis: Comparison with<scp>MRI<\/scp>and<scp>EEG<\/scp>findings"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-1037","authenticated-orcid":false,"given":"Chenpeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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