{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:17:31Z","timestamp":1781237851640,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the presence and relationship of temporal speech and gait parameters in patients with postural instability\/gait disorder (PIGD) and tremor\u2010dominant (TD) motor subtypes of Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Speech samples and instrumented walkway system assessments were acquired from a total of 60 de\u2010novo PD patients (40 in TD and 20 in PIGD subtype) and 40 matched healthy controls. Objective acoustic vocal assessment of seven distinct speech timing dimensions was related to instrumental gait measures including velocity, cadence, and stride length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, PIGD subtype showed greater consonant timing abnormalities by prolonged voice onset time (VOT) while also shorter stride length during both normal walking and dual task, while decreased velocity and cadence only during dual task. Speaking rate was faster in PIGD than TD subtype. In PIGD subtype, prolonged VOT correlated with slower gait velocity (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.56, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and shorter stride length (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.59, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) during normal walking, whereas relationships were also found between decreased cadence in dual task and irregular alternating motion rates (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.48, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) and prolonged pauses (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.50, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). No correlation between speech and gait was detected in TD subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that speech and gait rhythm disorder share similar underlying pathomechanisms specific for PIGD subtype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14158","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T08:14:58Z","timestamp":1679386498000},"page":"2101-2110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Speech and gait abnormalities in motor subtypes of de\u2010novo Parkinson's disease"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-3054","authenticated-orcid":false,"given":"Jan","family":"Rusz","sequence":"first","affiliation":[{"name":"Department of Circuit Theory, Faculty of Electrical Engineering Czech Technical University in Prague  Prague Czechia"},{"name":"Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital  Prague Czechia"},{"name":"Department of Neurology &amp; 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