{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:22:49Z","timestamp":1783538569076,"version":"3.55.0"},"reference-count":100,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62106032"],"award-info":[{"award-number":["62106032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62171073"],"award-info":[{"award-number":["62171073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972160"],"award-info":[{"award-number":["81972160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Schizophrenia is associated with abnormal hippocampal structure and function. Available evidence suggests that the anterior and posterior hippocampus are differentially affected by schizophrenia pathology. This study was designed to provide new insight into the anterior and posterior hippocampus in schizophrenia from the perspective of functional connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on resting\u2010state functional magnetic resonance imaging data of 71 schizophrenia patients and 74 normal controls, we utilized a data\u2010driven approach to functionally segment the hippocampus into anterior and posterior segments and then investigated the functional connectivity patterns within and between the two hippocampal networks at the network, edge, and nodal levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that schizophrenia patients showed hyperconnectivity of both the anterior and posterior hippocampal networks. We also observed that the network alterations appear somewhat greater in the anterior hippocampal network than the posterior network, the left side than the right, and the intranetwork connectivity than the internetwork connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results reveal convergent and divergent intranetwork and internetwork connectivity patterns of the anterior and posterior hippocampus in schizophrenia, providing novel and important insights into the mechanisms of hippocampal pathology in schizophrenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14171","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T05:09:24Z","timestamp":1679548164000},"page":"2223-2235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aberrant intra\u2010 and internetwork functional connectivity patterns of the anterior and posterior hippocampal networks in schizophrenia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-9366","authenticated-orcid":false,"given":"Xin\u2010Wei","family":"Li","sequence":"first","affiliation":[{"name":"School of Bioinformatics Chongqing University of Posts and Telecommunications  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Bioinformatics Chongqing University of Posts and Telecommunications  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Yang","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Bioinformatics Chongqing University of Posts and Telecommunications  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang\u2010Yong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Bioinformatics Chongqing University of Posts and Telecommunications  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Bioinformatics Chongqing University of Posts and Telecommunications  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biological Science &amp; Medical Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16549"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.09.041"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.249"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.10.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.01.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.12.026"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070981"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bionps.2020.100026"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20030340"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.486811"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.11.039"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv228"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.11.021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3785"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.03.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.07.008"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.06.054"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.09.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.02.019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2010_43"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20292"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.07.016"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.115"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19020151"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.02.005"},{"issue":"1","key":"e_1_2_10_27_1","first-page":"1","article-title":"Adverse clinical outcomes in people at clinical high\u2010risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function","volume":"11","author":"Allen P","year":"2021","journal-title":"Transl Psychiatry"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbz089"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.09.022"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(97)00140-0"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.02.001"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2012.02.001"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118149"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2575"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3214"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9793-9"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160008"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2016.08.001"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.783634"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.10.071"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09060802"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07010042"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.06.060"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr268"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.053"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2482"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21333"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.11.031"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4281-13.2014"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22644"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00077.2008"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3711-11.2012"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.10.014"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.036"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90777.2008"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.047"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3188-14.2015"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.12.002"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021976"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022288118"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255905"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5698-11.2012"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.155"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.110.1.40"},{"issue":"2","key":"e_1_2_10_68_1","first-page":"425","article-title":"White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs","volume":"43","author":"Klauser P","year":"2017","journal-title":"Schizophr Bull"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068910"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-18638-7_4"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20993"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby075"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107426"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.194"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4022-y"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.122"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.029"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01465"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby132"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00424"},{"key":"e_1_2_10_81_1","first-page":"92","article-title":"Increased amplitude of low frequency fluctuations but normal hippocampal\u2010default mode network connectivity in schizophrenia","volume":"6","author":"McHugo M","year":"2015","journal-title":"Front Psych"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.06.004"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbz076"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00985-1"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.11.011"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.046"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25625"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2847-07.2007"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00879-0"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0830"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22427"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0853-y"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1300.006"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704105080"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.01.013"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00278"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12031"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-021-00147-2"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.099"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00783.2009"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.14171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.14171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.14171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T18:36:06Z","timestamp":1692297366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.14171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":100,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/cns.14171"],"URL":"https:\/\/doi.org\/10.1111\/cns.14171","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]},"assertion":[{"value":"2022-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}