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Participants completed the Wechsler memory assessment and a short\u2010term memory game on an automated computer\u2010based memory assessment platform with an eye tracker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the MRI\u2010neg MTLE and HS\u2010MTLE groups took longer time to complete the short\u2010term memory game than healthy controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, Cohen's d\u2009=\u20091.087; <jats:italic>p<\/jats:italic>\u2009=\u20090.047, Cohen's d\u2009=\u20090.787). During the memory encoding phase, the MRI\u2010neg MTLE group spent significantly shorter time than healthy controls on the difficult levels with three (<jats:italic>p<\/jats:italic>\u2009=\u20090.004, Cohen's d\u2009=\u20090.993) and four targets (<jats:italic>p<\/jats:italic>\u2009=\u20090.016, Cohen's d\u2009=\u20090.858). During the memory decoding phase, the HS\u2010MTLE group spent less time looking on the targets compared to controls when recalling and finding four targets (<jats:italic>p<\/jats:italic>\u2009=\u20090.004, Cohen's d\u2009=\u2009\u22120.793), while the MRI\u2010neg MTLE group spent significantly longer time on the distractors and shorter time on the region of interests (ROIs) for all difficulty levels (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) than controls. Furthermore, the eye tracking data were correlated with the scores of the Wechsler Memory Scale after Bonferroni correction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with MRI\u2010neg MTLE demonstrate impaired memory mostly due to attention deficits, while those with HS\u2010MTLE show memory impairment with relative sparing of attention. Eye tracking technology has the potential of facilitating the investigation of the mechanism of memory defect in MTLE and can serve as a supplementary neuropsychological tool for clinical diagnosis and long\u2010term monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14203","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T07:21:06Z","timestamp":1681111266000},"page":"2621-2633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Memory characteristics in mesial temporal lobe epilepsy: Insights from an eye tracking memory game and neuropsychological assessments"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-4000","authenticated-orcid":false,"given":"Ling","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangpu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Spectral Imaging Technology Xi'an Institute of Optics and Precision Mechanics of the Chinese Academy of Sciences  Xi'an 710119 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"},{"name":"Key Laboratory of Biomedical Spectroscopy of Xi'an Xi'an Institute of Optics and Precision Mechanics of the Chinese Academy of Sciences  Xi'an 710119 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirui","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7658-1399","authenticated-orcid":false,"given":"Li","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4426-3449","authenticated-orcid":false,"given":"Beibin","family":"Li","sequence":"additional","affiliation":[{"name":"Paul G. 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