{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:58:42Z","timestamp":1790049522398,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071254"],"award-info":[{"award-number":["82071254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Parkinson's disease (PD) is a pervasive neurodegenerative disease, and levodopa (L\u2010dopa) is its preferred treatment. The pathophysiological mechanism of levodopa\u2010induced dyskinesia (LID), the most common complication of long\u2010term L\u2010dopa administration, remains obscure. Accumulated evidence suggests that the dopaminergic as well as non\u2010dopaminergic systems contribute to LID development. As a <jats:italic>5<\/jats:italic>\u2010<jats:italic>hydroxytryptamine<\/jats:italic> 1A\/1B receptor agonist, eltoprazine ameliorates dyskinesia, although little is known about its electrophysiological mechanism. The aim of this study was to investigate the cumulative effects of chronic L\u2010dopa administration and the potential mechanism of eltoprazine's amelioration of dyskinesia at the electrophysiological level in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Neural electrophysiological analysis techniques were conducted on the acquired local field potential (LFP) data from primary motor cortex (M1) and dorsolateral striatum (DLS) during different pathological states to obtain the information of power spectrum density, theta\u2010gamma phase\u2013amplitude coupling (PAC), and functional connectivity. Behavior tests and AIMs scoring were performed to verify PD model establishment and evaluate LID severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We detected exaggerated gamma activities in the dyskinetic state, with different features and impacts in distinct regions. Gamma oscillations in M1 were narrowband manner, whereas that in DLS had a broadband appearance. Striatal exaggerated theta\u2010gamma PAC in the LID state contributed to broadband gamma oscillation, and aperiodic\u2010corrected cortical beta power correlated robustly with aperiodic\u2010corrected gamma power in M1. M1\u2013DLS coherence and phase\u2010locking values (PLVs) in the gamma band were enhanced following L\u2010dopa administration. Eltoprazine intervention reduced gamma oscillations, theta\u2013gamma PAC in the DLS, and coherence and PLVs in the gamma band to alleviate dyskinesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Excessive cortical gamma oscillation is a compelling clinical indicator of dyskinesia. The detection of enhanced PAC and functional connectivity of gamma\u2010band oscillation can be used to guide and optimize deep brain stimulation parameters. Eltoprazine has potential clinical application for dyskinesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14241","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T05:51:18Z","timestamp":1682920278000},"page":"2998-3013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Eltoprazine modulated gamma oscillations on ameliorating L\u2010dopa\u2010induced dyskinesia in rats"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-9751","authenticated-orcid":false,"given":"Yuewei","family":"Bi","sequence":"first","affiliation":[{"name":"Neurosurgery Center, Department of Pediatric Neurosurgery, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Southern Medical University  Guangzhou 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