{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:12:33Z","timestamp":1787170353715,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071291"],"award-info":[{"award-number":["82071291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate changes in dynamic cerebral autoregulation (dCA), 20 stroke\u2010related blood biomarkers, and autonomic regulation after patent foramen ovale (PFO) closure in severe migraine patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patent foramen ovale severe migraine patients, matched non\u2010PFO severe migraine patients, and healthy controls were included. dCA and autonomic regulation were evaluated in each participant at baseline, and within 48\u2010h and 30\u2009days after closure in PFO migraineurs. A panel of stroke\u2010related blood biomarkers was detected pre\u2010surgically in arterial\u2010and venous blood, and post\u2010surgically in the arterial blood in PFO migraineurs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010five PFO severe migraine patients, 50 non\u2010PFO severe migraine patients, and 50 controls were enrolled. The baseline dCA function of PFO migraineurs was significantly lower than that of non\u2010PFO migraineurs and controls but was rapidly improved with PFO closure, remaining stable at 1\u2010month follow\u2010up. Arterial blood platelet\u2010derived growth factor\u2010BB (PDGF\u2010BB) levels were higher in PFO migraineurs than in controls, which was immediately and significantly reduced after closure. No differences in autonomic regulation were observed among the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patent foramen ovale closure can improve dCA and alter elevated arterial PDGF\u2010BB levels in migraine patients with PFO, both of which may be related to the preventive effect of PFO closure on stroke occurrence\/recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14244","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T01:22:04Z","timestamp":1683595324000},"page":"3031-3042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes in cerebral autoregulation, stroke\u2010related blood biomarkers, and autonomic regulation after patent foramen ovale closure in severe migraine 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