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The connectomes were further validated with 17 drug\u2010na\u00efve patients to verify their replication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The connectomes related to AR and tremor were identified via CPM method and successfully validated in the independent set. Additional regional\u2010based CPM demonstrated neither AR nor tremor could be simplified to functional changes within a single brain region. Computational lesion version of CPM revealed that parietal lobe and limbic system were the most important regions among AR\u2010related connectome, and motor strip and cerebellum were the most important regions among tremor\u2010related connectome. Comparing two connectomes found that the patterns of connection between them were largely distinct, with only four overlapped connections identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AR and tremor were found to be associated with functional changes in multiple brain regions. Distinct connection patterns of AR\u2010related and tremor\u2010related connectomes suggest different neural mechanisms underlying the two symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14284","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T08:21:15Z","timestamp":1686558075000},"page":"3507-3517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Functional connectomes of akinetic\u2010rigid and tremor within drug\u2010na\u00efve Parkinson's disease"],"prefix":"10.1111","volume":"29","author":[{"given":"Haoting","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital 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