{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:54:00Z","timestamp":1792457640991,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to investigate the association of the left ventricular ejection fraction (LVEF) spectrum with 1\u2010year clinical outcomes in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective registry for the Third China National Stroke Registry (CNSR\u2010III), AIS or TIA patients with echocardiography records during hospitalization were recruited. All LVEFs were categorized into intervals of 5% in width. The lowest and highest intervals are \u226440% and &gt;70%, respectively. The primary outcome was all\u2010cause death at 1\u2009year. Cox proportional hazards regression analysis was performed to investigate the association between baseline LVEF and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This analysis included a total of 14,053 patients. In total, 418 patients died during 1\u2010year follow\u2010up. Overall, LVEF \u226460% was associated with a higher risk of all\u2010cause death compared to LVEF &gt;60%, independent of demographic and clinical characteristics (aHR 1.29 [95% CI 1.06\u20131.58]; <jats:italic>p<\/jats:italic>\u2009=\u20090.01). The cumulative incidence of all\u2010cause death was significantly different among the eight LVEF groups that survival declined successively with the decrease of LVEF (log\u2010rank <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with AIS or TIA with decreased LVEF (\u226460%) had a lower 1\u2010year survival rate after onset. LVEF 50%\u201360% even within the normal range, may still contribute to poor outcomes in AIS or TIA. Comprehensive evaluation of cardiac function after acute ischemic cerebrovascular disease should be strengthened.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14285","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T06:29:06Z","timestamp":1686205746000},"page":"3518-3527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of left ventricular ejection fraction Spectrum on <scp>1\u2010Year<\/scp> mortality in patients with acute ischemic stroke or transient ischemic attack"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-6852","authenticated-orcid":false,"given":"Na","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing 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Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing 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