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This investigation aims to evaluate the main active compound of CF in antidepressant properties and its key target.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Firstly, this study established a behavioral despair model and used high\u2010performance liquid chromatography method to evaluate the antidepressant\u2010like effects of water extract, 20%, 50%, and 80% ethanol extracts of CF, and its main active compound. Then, this study created chronic unpredictable mild stress (CUMS) model to assess loganin's antidepressant\u2010like properties, and its target was evaluated by quantitative real\u2010time polymerase chain reaction, Western blot, Immunofluorescence, enzyme\u2010linked immunosorbent assay, and tyrosine receptor kinase B (TrkB) inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed that the different extracts of CF significantly shortened the immobility time in forced swimming and tail suspension tests. Moreover, loganin alleviated CUMS\u2010induced depression\u2010like behavior, promoted neurotrophy and neurogenesis, and inhibited neuroinflammation. Furthermore, K252a blocked the improvement of loganin on depression\u2010like behavior, and eliminated the enhancement of neurotrophy and neurogenesis and the inhibition of neuroinflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, these results indicated that loganin could be used as a major active compound of CF for the antidepressant\u2010like properties and exerted antidepressant\u2010like actions by regulating brain derived neurotrophic factor (BDNF)\u2013TrkB signaling, and TrkB could be used as key target for itsantidepressant\u2010like actions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14305","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T06:35:27Z","timestamp":1688625327000},"page":"3842-3853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of BDNF\u2013TrkB signaling in the antidepressant\u2010like actions of loganin, the main active compound of Corni Fructus"],"prefix":"10.1111","volume":"29","author":[{"given":"Mingzhu","family":"Gong","sequence":"first","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-551X","authenticated-orcid":false,"given":"Junming","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Co\u2010Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan &amp; Education Ministry of P.R. 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