{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:38:08Z","timestamp":1783442288214,"version":"3.54.6"},"reference-count":234,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pituitary adenomas (PAs), or pituitary neuroendocrine tumors (PitNETs), are commonly found in the anterior pituitary gland. Although the majority of PitNETs are benign and stable, several tumors have malignant characteristics. The tumor microenvironment (TME) plays an important role in the process of tumorigenesis and is composed of several types of cells. Various cells in the TME are significantly affected by oxidative stress. It has been reported that immunotherapeutic strategies have good effects in several cancers. However, the clinical potential of immunotherapies in PitNETs has not yet been fully discussed. Oxidative stress can regulate PitNET cells and immune cells in the TME, thus affecting the immune status of the TME of PitNETs. Therefore, modulation of oxidative stress\u2010regulated immune cells using a combination of several agents and the immune system to suppress PitNETs is a promising therapeutic direction. In this review, we systematically analyzed the oxidative stress process within PitNET cells and various immune cells to elucidate the potential value of immunotherapy.<\/jats:p>","DOI":"10.1111\/cns.14315","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T10:15:36Z","timestamp":1687342536000},"page":"2744-2759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oxidative stress in pituitary neuroendocrine tumors: Affecting the tumor microenvironment and becoming a new target for pituitary neuroendocrine tumor therapy"],"prefix":"10.1111","volume":"29","author":[{"given":"Yuhang","family":"Zhou","sequence":"first","affiliation":[{"name":"The First Clinical Medical College Heilongjiang University of Chinese Medicine Harbin China"},{"name":"Health Management Center Tongde Hospital of Zhejiang Province Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyou","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai General Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Public Health, School of Medicine Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwen","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, School of Medicine Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7099-5242","authenticated-orcid":false,"given":"Danyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Health Management Center Tongde Hospital of Zhejiang Province Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09703-7"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"319","article-title":"Pituitary adenomas: an overview","volume":"88","author":"Lake MG","year":"2013","journal-title":"Am Fam Physician"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2015.00141"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7103720"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0796"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0139"},{"issue":"2","key":"e_1_2_11_8_1","first-page":"147","article-title":"\u201cThe adrenal gland: central relay in health and disease \u2013 current challenges and perspectives 2018\u201d \u2013 Cushing's disease","volume":"127","author":"Stalla GK","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/17446651.2016.1153422"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-019-09598-x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30360"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.09.006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00292"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101605"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190215121712"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i3.456"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156906"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3368-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_862_16"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.116392"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.07.039"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123802"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.03.004"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103285"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-011-0293-3"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geq051"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-409-8_16"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2020.0084"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.10.004"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00874-8"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh245"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.520"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.327"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.74.4.1312542"},{"issue":"4","key":"e_1_2_11_37_1","first-page":"842","article-title":"H\u2010ras mutations in human pituitary carcinoma metastases","volume":"78","author":"Pei L","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"e_1_2_11_38_1","first-page":"409","article-title":"The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid","volume":"64","author":"Korbecki J","year":"2013","journal-title":"J Physiol Pharmacol"},{"issue":"6","key":"e_1_2_11_39_1","first-page":"649","article-title":"Activation of Keap1\/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells","volume":"6","author":"Huo L","year":"2014","journal-title":"Am J Transl Res"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-3-13"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00835"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.10.006"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.12.4914-4923.2005"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.01.009"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.02.010"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2014.45"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113663"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081935"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190710074"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.225680.113"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.034"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21396"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1958174"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948902"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.565748"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1667454"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2020.108586"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128502"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.10.012"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06376.x"},{"issue":"10","key":"e_1_2_11_61_1","first-page":"6585","article-title":"Pituitary adenylate cyclase\u2010activating polypeptide ameliorates radiation\u2010induced cardiac injury","volume":"11","author":"Li H","year":"2019","journal-title":"Am J Transl Res"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-014-0069-6"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00690"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04366-5"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.739631"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5652586"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154237"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0345"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05214.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.2741\/2002"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-007-9083-0"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2018.08.010"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-017-9552-y"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0027"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0706596"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0506"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.69"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.11.005"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.8.6754"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0346-8"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02738884"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02739874"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518808112"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051089"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.767"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15017502"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19516.x"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0264-6"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0026"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13577"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2011.03.005"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.038"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204206"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-4-1981"},{"issue":"2","key":"e_1_2_11_96_1","first-page":"509","article-title":"Transforming growth factor\u2010beta, transforming growth factor\u2010beta receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries","volume":"151","author":"Jin L","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0767"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02914990"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12117"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1211777"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00207.2015"},{"issue":"10","key":"e_1_2_11_102_1","article-title":"Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif\u20101\u03b1induced IL\u201010","volume":"5","author":"Ambade A","year":"2016","journal-title":"Onco Targets Ther"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26775"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1418"},{"issue":"1","key":"e_1_2_11_105_1","first-page":"1","article-title":"Tumor associated macrophage: a review on the phenotypes, traits and functions","volume":"7","author":"Ramanathan S","year":"2014","journal-title":"Iran J Cancer Prev"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802740"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.101"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101891"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.01.004"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071748"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13050986"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134791"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-2-20"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9383-6"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051845"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.004"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1782"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.05.001"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5851"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091415"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012016107"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016013"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84181"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2020.03.007"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3868"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02126-5"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901662"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.020"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620433114"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI155224"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80072-2"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.06.009"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.009"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00834-9"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02145-y"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3478"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-013-8266-6"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061909-093311"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05676-6"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf2341"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat2184"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1582"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0061-z"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2020.101407"},{"key":"e_1_2_11_145_1","first-page":"225","article-title":"The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer","volume":"395","author":"Cichocki F","year":"2016","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.018"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.610789"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3838"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.023"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12034"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00121"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444676"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402099"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76555-8"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117403"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.608422"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-203141"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-271874"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80011"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad7118"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-796342"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23161"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01337"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12170"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-1113"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.07.023"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100005X57346"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.07.014"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.047"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1292-2"},{"issue":"3","key":"e_1_2_11_171_1","first-page":"1997","article-title":"ERK\/MAPK signalling pathway and tumorigenesis","volume":"19","author":"Guo YJ","year":"2020","journal-title":"Exp Ther Med"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4035310"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00330"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.619567"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2018.04.012"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02396.x"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08010.x"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.537"},{"issue":"19","key":"e_1_2_11_179_1","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.3760\/cma.j.issn.0366-6999.20122929","article-title":"Interventions to improve chronic cyclosporine A nephrotoxicity through inhibiting renal cell apoptosis: a systematic review","volume":"126","author":"Xiao Z","year":"2013","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25140"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.08.019"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.06.054"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108981"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.01.007"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200301150-00004"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00199.2009"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-8-76"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.02.039"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.01.091"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1526-0"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2020.05.006"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58081095"},{"issue":"6","key":"e_1_2_11_193_1","first-page":"9079","article-title":"Gossypol acetate induced apoptosis of pituitary tumor cells by targeting the BCL\u20102 via the upregulated microRNA miR\u201015a","volume":"8","author":"Tang J","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"e_1_2_11_194_1","first-page":"945","article-title":"Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF\u20101\u03b1\/ROS\/VEGF","volume":"43","author":"Cheng J","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.03.054"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26752"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2019.08.002"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00403.x"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22917"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13752"},{"issue":"12","key":"e_1_2_11_201_1","first-page":"1073","article-title":"Radioprotective effect of a combination of melatonin and metformin on mice spermatogenesis: a histological study","volume":"18","author":"Tajabadi E","year":"2020","journal-title":"Int J Reprod Biomed"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174365"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00151"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040521"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01914"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02477-z"},{"issue":"24","key":"e_1_2_11_207_1","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.3760\/cma.j.issn.0366-6999.20131965","article-title":"Elevated levels of mitochonrial respiratory complexes activities and ATP production in 17\u2010\u03b2\u2010estradiol\u2010induced prolactin\u2010secretory tumor cells in male rats are inhibited by melatonin in vivo and in vitro","volume":"126","author":"Wang BQ","year":"2013","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00305.x"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8965903"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100284"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c21743"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.11.030"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01029"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6284124"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001392"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.03.033"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.07.006"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-020-01885-3"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00056"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.004"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.068"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98949-y"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.1873977"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24015"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0223-0"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1876-0"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.08.012"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.564"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105824"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0562-4"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay8707"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1908158117"},{"issue":"1","key":"e_1_2_11_233_1","article-title":"Downregulation of PD\u2010L1 via FKBP5 by celecoxib augments antitumor effects of PD\u20101 blockade in a malignant glioma model","volume":"2","author":"Yamaguchi I","year":"2020","journal-title":"Neurooncol Adv"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00348-4"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4664651"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.14315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T18:36:46Z","timestamp":1729622206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.14315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":234,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/cns.14315"],"URL":"https:\/\/doi.org\/10.1111\/cns.14315","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]},"assertion":[{"value":"2023-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}