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The specific role of white matter (WM) alteration in patients with glioma\u2010related epilepsy (GRE) is largely unknown. This study aims to investigate the reorganization of WM tracts and changes in structural networks related to GRE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diffusion\u2010weighted images were collected from 70 patients with left frontal DLGG (GRE\u2009=\u200933, non\u2010GRE\u2009=\u200937) and 41 healthy controls (HC). Tractometry with TractSeg was applied to segment tracts and quantify fractional anisotropy (FA) along each tract. Structural network was constructed using constrained spherical deconvolution and probabilistic tractography. FA and network properties were compared among three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HC, both GRE and non\u2010GRE showed decreased FA in contralateral inferior fronto\u2010occipital fasciculus, superior longitudinal fasciculus II and arcuate fasciculus, increased nodal efficiency in contralateral nodes of frontal\u2013parietal and limbic networks, whereas decreased degree centrality and betweenness centrality in nodes of dorsal temporal lobe and rostral middle frontal gyrus (rMFG). Additionally, when compared GRE with non\u2010GRE, increased FA in contralateral corticospinal tract (CST) and lower betweenness centrality in paracentral lobule (PCL) in GRE (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 after Bonferroni correction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicates that patients with left frontal DLGG exhibit complex WM reorganization, and the altered regions mainly concentrated in the language, frontal\u2013parietal and limbic networks. Moreover, the preserved integrity in contralateral CST and server decreased nodal betweenness in PCL may be potential neuroimaging markers underlying the occurrence of presurgical seizures of GRE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14322","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T06:45:44Z","timestamp":1688021144000},"page":"2366-2376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multiparametric mapping of white matter reorganizations in patients with frontal glioma\u2010related epilepsy"],"prefix":"10.1111","volume":"29","author":[{"given":"Simin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Department of Radiology West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology 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