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However, the underlying mechanisms remain unclear. This study aimed to determine the potential mechanisms of PBM in NP relief after SCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed systematic observations and investigated the mechanism of PBM intervention in NP in rats after SCI. Using transcriptome sequencing, we screened CXCL10 as a possible target molecule for PBM intervention and validated the results in rat tissues using reverse transcription\u2010polymerase chain reaction and western blotting. Using immunofluorescence co\u2010labeling, astrocytes and microglia were identified as the cells responsible for CXCL10 expression. The involvement of the NF\u2010\u03baB pathway in CXCL10 expression was verified using inhibitor pyrrolidine dithiocarbamate (PDTC) and agonist phorbol\u201012\u2010myristate\u201013\u2010acetate (PMA), which were further validated by an in vivo injection experiment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Here, we demonstrated that PBM therapy led to an improvement in NP relative behaviors post\u2010SCI, inhibited the activation of microglia and astrocytes, and decreased the expression level of CXCL10 in glial cells, which was accompanied by mediation of the NF\u2010\u03baB signaling pathway. Photobiomodulation inhibit the activation of the NF\u2010\u03baB pathway and reduce downstream CXCL10 expression. The NF\u2010\u03baB pathway inhibitor PDTC had the same effect as PBM on improving pain in animals with SCI, and the NF\u2010\u03baB pathway promoter PMA could reverse the beneficial effect of PBM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results provide new insights into the mechanisms by which PBM alleviates NP after SCI. We demonstrated that PBM significantly inhibited the activation of microglia and astrocytes and decreased the expression level of CXCL10. These effects appear to be related to the NF\u2010\u03baB signaling pathway. Taken together, our study provides evidence that PBM could be a potentially effective therapy for NP after SCI, CXCL10 and NF\u2010kB signaling pathways might be critical factors in pain relief mediated by PBM after SCI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14325","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T04:55:50Z","timestamp":1689915350000},"page":"3995-4017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Photobiomodulation reduces neuropathic pain after spinal cord injury by downregulating <scp>CXCL10<\/scp> expression"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-4547","authenticated-orcid":false,"given":"Zhihao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Xijing Hospital, Air Force Military Medical University  Xi'an Shaanxi 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