{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:51:37Z","timestamp":1787064697179,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate whether quetiapine monotherapy or in combination with lithium significantly disturbs thyroid function in depressed patients with bipolar disorder (BD), and whether difference exists in the post\u2010treatment thyroid function between the two therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on the electric medical records, outpatients and inpatients with a current depressive episode of BD from January 2016 to December 2022 were screened. All patients were treated with quetiapine monotherapy or in combination with lithium. In addition to the demographic data and depression scale, thyroid profiles including total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), thyroid\u2010stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and antithyroglobulin antibody (TGAb) were recorded, analyzed, and compared before and after the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Totally, 73 eligible patients were enrolled, including 53 in the monotherapy group (MG) and 20 in the combined therapy group (CG). No significant differences in thyroid profiles were detected between the two groups at the baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). After one\u2010month treatment, in the MG, serum levels of TT4, TT3, FT4, and FT3 reduced significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while TSH, TPOAb, and TGAb increased significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the CG, serum levels of TT4, TT3, and FT4 reduced and TSH increased following one\u2010month treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with no significant change in FT3, TPOAb, or TGAb (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). After one\u2010month treatment, no difference of TT4, TT3, FT4, FT3, and TSH was found between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both quetiapine monotherapy and a combined therapy with lithium significantly disturbed thyroid function in patients with bipolar depression, while quetiapine monotherapy seems to be associated with immune dysregulation in the thyroid.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14342","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T01:44:44Z","timestamp":1688953484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The impact of quetiapine monotherapy or in combination with lithium on the thyroid function in patients with bipolar depression: A retrospective study"],"prefix":"10.1111","volume":"30","author":[{"given":"Lingzhuo","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Psychiatry Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-670X","authenticated-orcid":false,"given":"Shaohua","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"The Key Laboratory of Mental Disorder's Management in Zhejiang Province  Hangzhou China"},{"name":"Brain Research Institute of 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