{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T21:39:49Z","timestamp":1778449189114,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971114"],"award-info":[{"award-number":["81971114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274401"],"award-info":[{"award-number":["82274401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ischemic stroke (IS) is a cerebrovascular disease with high incidence and mortality. White matter repair plays an important role in the long\u2010term recovery of neurological function after cerebral ischemia. Neuroprotective microglial responses can promote white matter repair and protect ischemic brain tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to investigate whether hypoxic postconditioning (HPC) can promote white matter repair after IS, and the role and mechanism of microglial polarization in white matter repair after HPC treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp; Methods<\/jats:title>\n                    <jats:p>Adult male C57\/BL6 mice were randomly divided into three groups: Sham group (Sham), MCAO group (MCAO), and hypoxic postconditioning group (HPC). HPC group were subjected to 45\u2009min of transient middle cerebral artery occlusion (MCAO) immediately followed by 40\u2009min of HPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed that HPC reduced the proinflammatory level of immune cells. Furthermore, HPC promoted the transformation of microglia to anti\u2010inflammatory phenotype on the third day after the procedure. HPC promoted the proliferation of oligodendrocyte progenitors and increased the expression of myelination\u2010related proteins on the 14th day. On the 28th day, HPC increased the expression of mature oligodendrocytes, which enhanced myelination. At the same time, the motor neurological function of mice was restored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>During the acute phase of cerebral ischemia, the function of proinflammatory immune cells was enhanced, long\u2010term white matter damage was aggravated, and motor sensory function was decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HPC promotes protective microglial responses and white matter repair after MCAO, which may be related to the proliferation and differentiation of oligodendrocytes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14346","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T04:45:40Z","timestamp":1689137140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hypoxic postconditioning drives protective microglial responses and ameliorates white matter injury after ischemic stroke"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-1118","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-1186","authenticated-orcid":false,"given":"Sijie","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Jun","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8796-1300","authenticated-orcid":false,"given":"Wantong","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorder Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"School of Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linhui","family":"Qin","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunlin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Neuroscience University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Senior Department of Oncology Fifth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-2744","authenticated-orcid":false,"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorder Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorder Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012781"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.13365"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_8_21"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-019-0689-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028143"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.05.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.04.022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.02.019"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.07.027"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_28_21"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186454"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.678744"},{"issue":"5","key":"e_1_2_9_16_1","first-page":"2006","article-title":"Modulators of microglia activation and polarization in ischemic stroke (review)","volume":"21","author":"Jiang C\u2010T","year":"2020","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.08.053"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1552127"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018505"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032444"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00388"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2018.02.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113871"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147044"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2016.1209"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135530"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.05.001"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13139"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0523"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03900-8"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802633R"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021113"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00957-y"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176253"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0545-3"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822dc7c8"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010066"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13366"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245330290028588"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00338-3"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.11.020"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040861"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00108"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.01.005"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_24_18"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.4103\/2394-8108.192517"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_6_21"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.727899"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_16_21"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199139"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010994"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4023"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020479"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0601-5"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.01.002"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33385"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.14346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.14346","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.14346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:21:30Z","timestamp":1771078890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.14346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,12]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/cns.14346"],"URL":"https:\/\/doi.org\/10.1111\/cns.14346","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,12]]},"assertion":[{"value":"2023-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14346"}}