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Here, we reviewed current knowledge indicating the potential involvement of autophagy dysregulation in mania and further discussed whether targeting autophagy could be a promising strategy for mania therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussions<\/jats:title><jats:p>Accumulating evidence indicated the involvement of autophagy in the pathology of mania. One of the most well\u2010accepted mechanisms underlying mania, circadian dysregulation, showed mutual interaction with autophagy dysfunction. In addition, several first\u2010line drugs for mania therapy were found to regulate neuronal autophagy. Besides, deficiencies in mitochondrial quality control, neurotransmission, and ion channel, which showed causal links to mania, were intimately associated with autophagy dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although more efforts should be made to either identify the key pathology of mania, the current evidence supported that autophagy dysregulation may act as a possible mechanism involved in the onset of mania\u2010like symptoms. It is therefore a potential strategy to treat manic disorder by correting autophagy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14353","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T05:20:55Z","timestamp":1689225655000},"page":"3684-3692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The engagement of autophagy in maniac disease"],"prefix":"10.1111","volume":"29","author":[{"given":"Yidong","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Pharmacology &amp; Toxicology, College of Pharmaceutical Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; Toxicology, College of Pharmaceutical Sciences Zhejiang University  Hangzhou 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