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Levodopa can reverse the clinical manifestations by modulating the function of motor circuits, but its detailed mechanisms are still not fully understood. We aimed to explore (1) the mechanism by which levodopa modulates the functional connectivity (FC) in the subregions of the thalamus; (2) the relationship between the changed FC and the improvement of motor symptoms in Parkinson's disease (PD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Resting\u2010state functional MRI was used to scan 36 PD patients and 37 healthy controls. The FC between the subregions in the thalamus and the whole brain was measured and compared under different medication states of PD patients. The correlation between the improvement of motor symptoms and changes in FC in the thalamus subregions was examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PD on state exhibited decreased FC between the right pre\u2010motor thalamus and the right postcentral gyrus, as well as the right lateral pre\u2010frontal thalamus and the right postcentral gyrus. These decreases were positively correlated with the improvement of resting tremor. The PD on state also exhibited decreased FC between the left lateral pre\u2010frontal thalamus and right paracentral lobule, which was positively correlated with the improvement of bradykinesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that levodopa treats\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      by decreasing the\n                      <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>\n                      between the thalamus subregions and pre\/post\u2010central cortex. Our results provide a basis for further exploration of the functional activity of thalamic subregions and offer new insights into the precision treatment in\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      patients\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14354","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T01:15:27Z","timestamp":1689383727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Levodopa improved different motor symptoms in patients with Parkinson's disease by reducing the functional connectivity of specific thalamic subregions"],"prefix":"10.1111","volume":"30","author":[{"given":"Wan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation The Affiliated Brain Hospital of Nanjing Medical University  Nanjing 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