{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:43:40Z","timestamp":1785516220552,"version":"3.56.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971271"],"award-info":[{"award-number":["81971271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201676"],"award-info":[{"award-number":["82201676"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ20H090013"],"award-info":[{"award-number":["LQ20H090013"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate whether peripheral T\u2010cell subsets could be a biomarker to distinguish major depressive disorder (MDD) and bipolar disorder (BD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Medical records of hospitalized patients in the Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, from January 2015 to September 2020 with a discharge diagnosis of MDD or BD were reviewed. Patients who underwent peripheral blood examination of T\u2010cell subtype proportions, including CD3+, CD4+, CD8+ T\u2010cell, and natural killer (NK) cells, were enrolled. The Chi\u2010square test,\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, or one\u2010way analysis of variance were used to analyze group differences. Demographic profiles and T\u2010cell data were used to construct a random forest classifier\u2010based diagnostic model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Totally, 98 cases of BD mania, 459 cases of BD depression (BD\u2010D), and 458 cases of MDD were included. There were significant differences in the proportions of CD3+, CD4+, CD8+ T\u2010cell, and NK cells among the three groups. Compared with MDD, the BD\u2010D group showed higher CD8+ but lower CD4+ T\u2010cell and a significantly lower ratio of CD4+ and CD8+ proportions. The random forest model achieved an area under the curve of 0.77 (95% confidence interval: 0.71\u20130.83) to distinguish BD\u2010D from MDD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings imply that BD and MDD patients may harbor different T\u2010cell inflammatory patterns, which could be a potential diagnostic biomarker for mood disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14361","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T01:32:31Z","timestamp":1690335151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circulating T\u2010cell subsets discrepancy between bipolar disorder\u00a0and major depressive disorder during mood episodes: A naturalistic, retrospective study of 1015 cases"],"prefix":"10.1111","volume":"30","author":[{"given":"Shaoli","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"The Key Laboratory of Mental Disorder's Management in Zhejiang Province  Hangzhou China"},{"name":"Department of Medical Oncology, The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Engineering Center for Mathematical Mental Health  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Shaoxing 7th People's Hospital  Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixi","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingle","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of 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