{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T15:07:48Z","timestamp":1771081668816,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Creutzfeldt\u2010Jakob disease (CJD) is a lethal neurodegenerative disorder, which leads to a rapidly progressive dementia. This study aimed to examine the cortical alterations in CJD, changes in these brain characteristics over time, and the differences between CJD and Alzheimer's disease (AD) that show similar clinical manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To obtain reliable, subject\u2010specific functional measures, we acquired 24\u2009min of resting\u2010state fMRI data from each subject. We applied an individual\u2010based approach to characterize the functional brain organization of 10 patients with CJD, 8 matched patients with AD, and 8 normal controls. We measured cortical atrophy as well as disruption in resting\u2010state functional connectivity (rsFC) and then investigated longitudinal brain changes in a subset of CJD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CJD was associated with widespread cortical thinning and weakened rsFC. Compared with AD, CJD showed distinct atrophy patterns and greater disruptions in rsFC. Moreover, the longitudinal data demonstrated that the progressive cortical thinning and disruption in rsFC mainly affected the association rather than the primary cortex in CJD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CJD shows unique anatomical and functional disruptions in the cerebral cortex, distinct from AD. Rapid progression of CJD affects both the cortical thickness and rsFC in the association cortex.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14404","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T05:30:13Z","timestamp":1691991013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Personalized brain MRI revealed distinct functional and anatomical disruptions in Creutzfeldt\u2010Jakob disease and Alzheimer's disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Yanjun","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxun","family":"Ren","sequence":"additional","affiliation":[{"name":"Changping Laboratory  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weigang","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Engineering Medicine Beihang University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Dahmani","sequence":"additional","affiliation":[{"name":"Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Changping Laboratory  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Li","sequence":"additional","affiliation":[{"name":"Changping Laboratory  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyi","family":"Li","sequence":"additional","affiliation":[{"name":"Changping Laboratory  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Friendship Hospital, Capital Medical University  Beijing 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