{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:25:53Z","timestamp":1774538753657,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endovascular treatment for patients with symptomatic nonacute middle cerebral artery occlusion remains clinically challenging, and proof of a beneficial effect on functional outcome is lacking. We aim to evaluate the effectiveness and safety of endovascular recanalization for patients with symptomatic nonacute middle cerebral artery occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010eight patients with symptomatic atherosclerotic nonacute middle cerebral artery occlusion were divided into drug treatment groups (42) and endovascular treatment groups (56). The rate of recanalization, peri\u2010procedural complications, and follow\u2010up results were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 56 patients who received endovascular treatment, 53 (94.6%) achieved successful recanalization. The rate of peri\u2010procedural complications was 7.1% (4\/56), and the death rate was 1.8% (1\/56). Any stroke within 90\u2009days was 7.1% (4\/56). Among the 42 patients in drug treatment group, any stroke within 90\u2009days was 19.0% (8\/42), death rate was 0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with symptomatic nonacute middle cerebral artery occlusion with a short length of occlusion and a moderate\u2010to\u2010good collateral circulation, endovascular treatment seems to be safe. And endovascular treatment could reduce the recurrence rate of stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14426","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:11:01Z","timestamp":1693296661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety and effectiveness assessment of endovascular recanalization for <scp>non\u2010acute<\/scp> middle cerebral artery occlusion"],"prefix":"10.1111","volume":"30","author":[{"given":"Zhang","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Drum Tower Hospital Nanjing University  Nanjing China"},{"name":"Jiangsu Province Stroke Center for Diagnosis and Therapy  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan","family":"Guangxin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Drum Tower Hospital Nanjing University  Nanjing China"},{"name":"Jiangsu Province Stroke Center for Diagnosis and Therapy  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Drum Tower Hospital Nanjing University  Nanjing China"},{"name":"Jiangsu Province Stroke Center for Diagnosis and Therapy  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhibin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Drum Tower Hospital Nanjing University  Nanjing China"},{"name":"Jiangsu Province Stroke Center for Diagnosis and Therapy  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luo","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Drum Tower Hospital Nanjing University  Nanjing China"},{"name":"Jiangsu Province Stroke Center for Diagnosis and Therapy  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Tingzheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Drum Tower Hospital Nanjing University  Nanjing China"},{"name":"Jiangsu Province Stroke Center for Diagnosis and Therapy  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-0319","authenticated-orcid":false,"given":"Xu","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Drum Tower Hospital Nanjing University  Nanjing China"},{"name":"Jiangsu Province Stroke Center for Diagnosis and Therapy  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-2776","authenticated-orcid":false,"given":"Li","family":"Jingwei","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Drum Tower Hospital Nanjing University  Nanjing China"},{"name":"Jiangsu Province Stroke Center for Diagnosis and Therapy  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043033"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4804"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-325630"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1516-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003508"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3960"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17732884"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30500-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31179-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70224-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.9.1287"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12062"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10250"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.505776"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1610"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390150059034"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.615955"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000086"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010304"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.039"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70251-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016692"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.14426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T14:02:38Z","timestamp":1716559358000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.14426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,29]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/cns.14426"],"URL":"https:\/\/doi.org\/10.1111\/cns.14426","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,29]]},"assertion":[{"value":"2023-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14426"}}