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Previous studies showed that HDAC6 knockdown or TubA can protect the TNF\u2010induced endothelial dysfunction. However, the role of HDAC6 inhibition on ICH\u2010induced BBB disruption remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hemin\u2010induced human brain microvascular endothelial cells (HBMECs) and collagenase\u2010induced rats were employed to investigated the underlying impact of the HDAC6 inhibition in BBB lesion and neuronal dysfunction after ICH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a significant decrease in acetylated \u03b1\u2010tubulin during early phase of ICH. Both 25 or 40\u2009mg\/kg of TubA could relieve neurological deficits, perihematomal cell apoptosis, and ipsilateral brain edema in ICH animal model. TubA or specific siRNA of HDAC6 inhibited apoptosis and reduced the endothelial permeability of HBMECs. HDAC6 inhibition rescued the degradation of TJ proteins and repaired TJs collapses after ICH induction. Finally, the results suggested that the protective effects on BBB after ICH induction were exerted via upregulating the acetylated \u03b1\u2010tubulin and reducing stress fiber formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inhibition of HDAC6 expression showed beneficial effects against BBB disruption after experimental ICH, which suggested that HDAC6 could be a novel and promising target for ICH treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14429","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:58:59Z","timestamp":1693828739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Selective <scp>HDAC6<\/scp> inhibition protects against blood\u2013brain barrier dysfunction after intracerebral hemorrhage"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-9527","authenticated-orcid":false,"given":"Cuiying","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Department of Neurology, Hunan Provincial Rehabilitation Hospital Hunan University of Medicine  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan 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