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Demographic information, cognitive function, the levels of neuropathological proteins and neuroinflammatory factors in cerebrospinal fluid (CSF) were compared between the two groups, and their correlations were subsequently analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\u03b2<\/jats:italic>\n                      amyloid protein (A\u03b2)\n                      <jats:sub>1\u201342<\/jats:sub>\n                      level from the\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carrier group was significantly lower than that from the non\u2010carrier group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023), which was associated with worse cognitive function. The nitric oxide (NO) level was significantly elevated in the\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carrier group compared to the non\u2010carrier group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), which was significantly and positively correlated with the Trail Making Test (TMT)\u2010A\u2010time (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) and TMT\u2010B\u2010time (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 is associated with poorer cognition, particularly the early symptoms of memory, language, and attention.\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 is associated with lower A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      level, and the more numbers of\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 are carried, the lower level of A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      is measured.\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 is associated with elevated NO level, which is linked to the impaired attention and executive function.\n                    <\/jats:p>\n                  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