{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:47:01Z","timestamp":1790178421913,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211008"],"award-info":[{"award-number":["BK20211008"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Previous studies have suggested that presbycusis (age\u2010related hearing loss) is accompanied with cognitive decline and dementia. However, the neural mechanism underlying the cognitive decline in presbycusis remains unclear. This study aimed to evaluate the glymphatic system function in presbycusis patients compared to healthy controls using diffusion tensor imaging (DTI) with the perivascular space (DTI\u2010ALPS) method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DTI scans were obtained from 30 presbycusis patients with cognitive decline (PCD), 30 presbycusis patients with no cognitive decline (PNCD) and 40 age\u2010, gender\u2010, and education\u2010matched healthy controls (HCs). The DTI\u2010ALPS index was calculated for each group. We evaluated the differences in the DTI\u2010ALPS index among PCD, PNCD and HCs. In addition, we conducted a correlation analysis between the DTI\u2010ALPS index and cognitive performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences of the DTI\u2010ALPS index among three groups. Post\u2010hoc analysis suggested that the DTI\u2010ALPS index in PCD was significantly lower patients in relative to PNCD and HCs (1.49147 vs. 1.57441 vs. 1.62020, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After correcting for age, gender, and education, the DTI\u2010ALPS index is positively correlated with the MoCA scores (rho\u2009=\u20090.426, <jats:italic>p<\/jats:italic>\u2009=\u20090.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Presbycusis patients with cognitive impairment exhibited decreased glymphatic activity than those without cognitive impairment and HCs. The DTI\u2010ALPS index may provide useful disease progression or treatment biomarkers for patients with presbycusis as an indicator of modulation of glymphatic activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14458","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T07:09:45Z","timestamp":1694156985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of glymphatic system activity by diffusion tensor image analysis along the perivascular space in presbycusis"],"prefix":"10.1111","volume":"30","author":[{"given":"Kaixi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiology Lianyungang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine  Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Yuhua Hospital Yuhua Branch of Nanjing First Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Nanjing First Hospital Nanjing Medical University  Nanjing 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