{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:35:16Z","timestamp":1793338516647,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Sleep is predicted as a key modulator of cognition, but the underlying mechanisms are poorly understood. In this study, we investigated the effects of melatonin on chronic rapid eye movement sleep deprivation (CRSD)\u2010induced cognitive impairment and circadian dysfunction in rat models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six Sprague\u2010Dawley male rats were divided into three groups: CRSD with saline treatment, CRSD with chronic melatonin injection (20\u2009mg\/kg\/day), and non\u2010sleep\u2010deprived control. The cognitive behavioral tests as well as the expression of clocks and HDAC3 were evaluated in all groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CRSD significantly reduced recognition index in novel object location, increased escape latency and distance traveling in Morris water maze while melatonin treatment attenuated CRSD\u2010induced hippocampal\u2010dependent spatial learning and memory deficits. Furthermore, the mRNAs of <jats:italic>brain and muscle aryl hydrocarbon receptor nuclear translocator\u2010like 1(Bmal1)<\/jats:italic> and <jats:italic>circadian locomotor output cycles kaput<\/jats:italic> (<jats:italic>Clock<\/jats:italic>) were globally down\u2010regulated by CRSD with constant intrinsic oscillation in both hippocampus and peripheral blood. The protein levels of hippocampal Bmal1, Clock, and HDAC3 were also remarkably down\u2010regulated following CRSD. Melatonin treatment reversed CRSD\u2010induced alterations of Bmal1\/Clock and HDAC3 on both mRNA levels and protein levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data indicate that melatonin treatment attenuates CRSD\u2010induced cognitive impairment via regulating HDAC3\u2010Bmal1\/Clock interaction. These findings explore a broader understanding of the relationship between sleep and cognition and provide a potential new therapeutic target for cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14474","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:10:02Z","timestamp":1695039002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Melatonin attenuates chronic sleep deprivation\u2010induced cognitive deficits and <scp>HDAC3\u2010Bmal1<\/scp>\/clock interruption"],"prefix":"10.1111","volume":"30","author":[{"given":"Yujie","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha China"},{"name":"Department of Neurology Haikou Affiliated Hospital of Central South University Xiangya School of Medicine  Haikou 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