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The accumulation of Amyloid <jats:italic>\u03b2<\/jats:italic> (A<jats:italic>\u03b2<\/jats:italic>) leads to an active environment during the early stages of Alzheimer's disease (AD). A<jats:italic>\u03b2<\/jats:italic> is also present in glioma tissues; however, the biological and translational implications of A<jats:italic>\u03b2<\/jats:italic> in glioma are elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemical (IHC) staining, Kaplan\u2013Meier (KM) survival analysis and Cox regression analysis on a cohort of 79 patients from our institution were performed to investigate the association between A<jats:italic>\u03b2<\/jats:italic> and the malignancy of glioma. Subsequently, the potential of oligomer\u2010A<jats:italic>\u03b2<\/jats:italic>42 (OA<jats:italic>\u03b2<\/jats:italic>42) to inhibit glioma growth was investigated <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Immunofluorescence staining and phagocytosis assays were performed to evaluate the activation of microglia. Finally, RNA\u2010seq was utilized to identify the predominant signaling involved in this process and <jats:italic>in vitro<\/jats:italic> studies were performed to validate them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A positive correlation between A<jats:italic>\u03b2<\/jats:italic> and a favorable prognosis was observed in glioma. Furthermore, OA<jats:italic>\u03b2<\/jats:italic>42 suppressed glioma growth by enhancing the phagocytic activity of microglia. Insulin\u2010like growth factor 1 (IGF\u20101) secreted by OA<jats:italic>\u03b2<\/jats:italic>42\u2010activated microglia was essential in the engulfment process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study proved an anti\u2010glioma effect of A<jats:italic>\u03b2<\/jats:italic>, and microglia could serve as a cellular target for treating glioma with OA<jats:italic>\u03b2<\/jats:italic>42.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14495","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T05:22:42Z","timestamp":1697606562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Oligomer\u2010A<i>\u03b2<\/i>42<\/scp> suppress glioma progression via potentiating phagocytosis of 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