{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:47:58Z","timestamp":1791895678276,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32230041"],"award-info":[{"award-number":["32230041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81920108016"],"award-info":[{"award-number":["81920108016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, but its pathogenesis remains incompletely understood, particularly the involvements of central nervous system sensitization in colorectal visceral pain. Our study was to investigate whether the paraventricular thalamus (PVT) projected to the insular cortex (IC) to regulate colorectal visceral pain in neonatal colonic inflammation (NCI) mice and underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We applied optogenetic, chemogenetic, or pharmacological approaches to manipulate the glutamatergic\n                      <jats:sup>PVT\u2010IC<\/jats:sup>\n                      pathway. Fiber photometry was used to assess neuronal activity. Electromyography activities in response to colorectal distension (CRD) were measured to evaluate the colorectal visceral pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NCI enhanced c\u2010Fos expression and calcium activity upon CRD in the IC\n                      <jats:sup>Glu<\/jats:sup>\n                      , and optogenetic manipulation of them altered colorectal visceral pain responses accordingly. Viral tracing indicated that the PVT\n                      <jats:sup>Glu<\/jats:sup>\n                      projected to the IC\n                      <jats:sup>Glu<\/jats:sup>\n                      . Optogenetic manipulation of PVT\n                      <jats:sup>Glu<\/jats:sup>\n                      changed colorectal visceral pain responses. Furthermore, selective optogenetic modulation of PVT projections in the IC influenced colorectal visceral pain, which was reversed by chemogenetic manipulation of downstream IC\n                      <jats:sup>Glu<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study identified a novel PVT\u2010IC neural circuit playing a critical role in colorectal visceral pain in a mouse model of IBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14534","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T19:40:19Z","timestamp":1700854819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Paraventricular thalamus\u2010insular cortex circuit mediates colorectal visceral pain induced by neonatal colonic inflammation in mice"],"prefix":"10.1111","volume":"30","author":[{"given":"Fu\u2010Chao","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow University  Suzhou Jiangsu P. 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