{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:41:55Z","timestamp":1780065715740,"version":"3.54.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["ZYGX2022YGRH017"],"award-info":[{"award-number":["ZYGX2022YGRH017"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071320"],"award-info":[{"award-number":["82071320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Cerebrovascular lesions in the primary visual cortex, the lateral geniculate nucleus, and the optic tract have been associated with retinal neurodegeneration via the retrograde degeneration (RD) mechanism. We aimed to use optical coherence tomography (OCT) to assess the effects of the strategic single subcortical infarction (SSI) location on retinal neurodegeneration and its longitudinal impacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SSI were enrolled and stratified by lesion location on cerebral MRI into the thalamic infarction group and extra\u2010thalamic infarction group. Healthy controls from the native communities were also recruited. Retinal nerve fiber layer (RNFL) and ganglion cell\u2010inner plexiform layer (GCIPL) were quantified using OCT. Generalized estimating equation (GEE) models were used for cross\u2010sectional analyses and linear mixed models for longitudinal analyses. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included a total of 283 eyes from 149 SSI patients. Of these, 115 eyes of 60 patients with follow\u2010up were included in the longitudinal analyses. Cross\u2010sectionally, thalamic\u2010infarction patients had reduced retinal thickness compared with extra\u2010thalamic infarction patients after adjustment for age, gender, disease duration, and vascular risk factors (<jats:italic>p<\/jats:italic>\u2009=\u20090.026 for RNFL, and <jats:italic>p<\/jats:italic>\u2009=\u20090.026 for GCIPL). Longitudinally, SSI patients showed greater retinal thinning compared with healthy controls over time (<jats:italic>p<\/jats:italic>\u2009=\u20090.040 for RNFL, and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for GCIPL), and thalamic infarction patients exhibited faster rates of GCIPL thinning in comparison with extra\u2010thalamic infarction patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates a distinct effect of subcortical infarction lesion site on the retina both at the early stage of disease and at the 1\u2010year follow\u2010up time. These results present evidence of significant associations between strategic infarction locations and retinal neurodegeneration. It may provide novel insights for further research on RD in stroke patients and ultimately facilitate individualized recovery therapeutic strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14543","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T11:04:45Z","timestamp":1701255885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Distinct alterations of retinal structure between thalamic and extra\u2010thalamic subcortical infarction patients: A cross\u2010sectional and longitudinal study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1857-2604","authenticated-orcid":false,"given":"Ruosu","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Cerebrovascular Diseases West China Hospital, Sichuan University  Chengdu 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