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The hallmark physiological function of IL\u201038 is competitive binding to IL\u201036R, as does the IL\u201036R antagonist. Emerging research has shown that IL\u201038 is abnormally expressed in the serum and brain tissue of patients with ischemic stroke (IS) and autism spectrum disorder (ASD), suggesting that IL\u201038 may play an important role in neurological diseases. Important advances include that IL\u201038 alleviates neuromyelitis optica disorder (NMOD) by inhibiting Th17 expression, improves IS by protecting against atherosclerosis via regulating immune cells and inflammation, and reduces IL\u20101\u03b2 and CXCL8 release through inhibiting human microglial activity post\u2010ASD. In contrast, IL\u201038 mRNA is markedly increased and is mainly expressed in phagocytes in spinal cord injury (SCI). IL\u201038 ablation attenuated SCI by reducing immune cell infiltration. However, the effect and underlying mechanism of IL\u201038 in CNS diseases remain inadequately characterized. In this review, we summarize the biological characteristics, pathophysiological role, and potential mechanisms of IL\u201038 in CNS diseases (e.g., NMOD, Alzheimer's disease, ASD, IS, TBI, and SCI), aiming to explore the therapeutic potential of IL\u201038 in the prevention and treatment of CNS diseases.<\/jats:p>","DOI":"10.1111\/cns.14550","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T05:55:28Z","timestamp":1707458128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Emerging functions and therapeutic targets of IL\u201038 in central nervous system diseases"],"prefix":"10.1111","volume":"30","author":[{"given":"Yuan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, School of Basic Medicine and Biological Sciences Soochow University  Suzhou China"},{"name":"Department of Neurosurgery Pennsylvania State University College of 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