{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T15:06:55Z","timestamp":1771081615739,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In \u03b1\u2010synucleinopathies, the dysfunction of the autonomic nervous system which typically manifests as orthostatic hypotension (OH) often leads to severe consequences and poses therapeutic challenges. This study aims to discover the brain\u2010cardiac electrophysiological changes in OH patients with \u03b1\u2010synucleinopathies using the rapid quantitative electroencephalography (qEEG) coupled with heart rate variability (HRV) technique to identify rapid, noninvasive biomarkers for early warning and diagnosis, as well as shed new light on complementary treatment approaches such as brain stimulation targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, 26 subjects of \u03b1\u2010synucleinopathies with OH (\u03b1\u2010OH group), 21 subjects of \u03b1\u2010synucleinopathies without OH (\u03b1\u2010NOH group), and 34 healthy controls (control group) were included from September 2021 to August 2023 (NCT05527067). The heart rate\u2010blood pressure variations in supine and standing positions were monitored, and synchronization parameters of seated resting\u2010state HRV coupled with qEEG were collected. Time\u2010domain and frequency\u2010domain of HRV measures as well as peak frequency and power of the brainwaves were extracted. Differences between these three groups were compared, and correlations between brain\u2010heart parameters were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The research results showed that the time\u2010domain parameters such as MxDMn, pNN50, RMSSD, and SDSD of seated resting\u2010state HRV exhibited a significant decrease only in the \u03b1\u2010OH group compared to the healthy control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while there was no significant difference between the \u03b1\u2010NOH group and the healthy control group. Several time\u2010domain and frequency\u2010domain parameters of seated resting\u2010state HRV were found to be correlated with the blood pressure changes within the first 5\u2009min of transitioning from supine to standing position (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Differences were observed in the power of beta1 waves (F4 and Fp2) and beta2 waves (Fp2 and F4) in the seated resting\u2010state qEEG between the \u03b1\u2010OH and \u03b1\u2010NOH groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The peak frequency of theta waves in the Cz region also showed a difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The power of beta2 waves in the Fp2 and F4 brain regions correlated with frequency\u2010domain parameters of HRV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Additionally, abnormal electrical activity in the alpha, theta, and beta1 waves was associated with changes in heart rate and blood pressure within the first 5\u2009min of transitioning from supine to standing position (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rapid resting\u2010state HRV with certain time\u2010domain parameters below normal levels may serve as a predictive indicator for the occurrence of orthostatic hypotension (OH) in patients with \u03b1\u2010synucleinopathies. Additionally, the deterioration of HRV parameters correlates with synchronous abnormal qEEG patterns, which can provide insights into the brain stimulation target areas for OH in \u03b1\u2010synucleinopathy patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14571","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T02:20:16Z","timestamp":1707358816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synchronous monitoring of brain\u2010heart electrophysiology using heart rate variability coupled with rapid quantitative electroencephalography in orthostatic hypotension patients with \u03b1\u2010synucleinopathies: Rapid prediction of orthostatic hypotension and preliminary exploration of brain stimulation therapy"],"prefix":"10.1111","volume":"30","author":[{"given":"Lin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, Center 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