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We used independent component analysis and graph theoretical analysis to determine the topologic characteristics of the brain and as well as functional network connectivity (FNC) and topologic properties of brain networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HCs, patients with DON showed altered global characteristics. At the nodal level, the DON group had fewer nodal degrees in the thalamus and insula, and a greater number in the right rolandic operculum, right postcentral gyrus, and right superior temporal gyrus. In the internetwork comparison, DON patients showed significantly increased FNC between the left frontoparietal network (FPN\u2010L) and ventral attention network (VAN). Additionally, in the intranetwork comparison, connectivity between the left medial superior frontal gyrus (MSFG) of the default network (DMN) and left putamen of auditory network was decreased in the DON group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DON patients altered node properties and connectivity in the DMN, auditory network, FPN\u2010L, and VAN. These results provide evidence of the involvement of specific brain networks in the pathophysiology of DON.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14579","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T11:45:35Z","timestamp":1710762335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting\u2010state functional magnetic resonance imaging study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1008-539X","authenticated-orcid":false,"given":"Qian","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for Metabolic Disease  Nanchang Jiangxi China"},{"name":"Queen Mary School The Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiology Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San\u2010Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010Lin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-2433","authenticated-orcid":false,"given":"Yi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Department of Ophthalmology Eye &amp; 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