{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T15:07:17Z","timestamp":1771081637476,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Most studies focus on dynamic cerebral autoregulation (dCA) in the middle cerebral artery (MCA), and few studies investigated neurovascular coupling (NVC) and dCA in the posterior cerebral artery (PCA). We investigated NVC and dCA of the PCA in healthy volunteers to identify sex differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty men and 30 age\u2010matched women completed dCA and NCV assessments. The cerebral blood flow velocity (CBFV) and mean arterial pressure were evaluated using transcranial Doppler ultrasound and a servo\u2010controlled plethysmograph, respectively. The dCA parameters were analyzed using transfer function analysis. The NCV was evaluated by eyes\u2010open and eyes\u2010closed (24\u2009s each) periodically based on voice prompts. The eyes\u2010open visual stimulation comprised silent reading of Beijing\u2010related tourist information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PCA gain was lower than that of the MCA in all frequency ranges (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Phase was consistent across the cerebrovascular territories. The cerebrovascular conductance index (CVCi) and mean CBFV (MV) of the PCA were significantly higher during the eyes\u2010open than eyes\u2010closed period (CVCi: 0.50\u2009\u00b1\u20090.12 vs. 0.38\u2009\u00b1\u20090.10; MV: 42.89\u2009\u00b1\u20098.49 vs. 32.98\u2009\u00b1\u20097.25, both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The PCA dCA and NVC were similar between the sexes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We assessed two major mechanisms that maintain cerebral hemodynamic stability in healthy men and women. The visual stimulation\u2010evoked CBFV of the PCA was significantly increased compared to that during rest, confirming the activation of NVC. Men and women have similar functions in PCA dCA and NCV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14584","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T06:49:51Z","timestamp":1707374991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparable dynamic cerebral autoregulation and neurovascular coupling of the posterior cerebral artery between healthy men and women"],"prefix":"10.1111","volume":"30","author":[{"given":"Hongxiu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Vascular Ultrasonography Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Diagnostic Center of Vascular Ultrasound  Beijing China"},{"name":"Center of Vascular Ultrasonography, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing 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