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Thus, we aimed to investigate the association between plasma CTRPs with Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A multicenter, cross\u2010sectional study recruited patients with AD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009137) and cognitively normal (CN) controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009140). After the data collection of demographic characteristics, lifestyle risk factors, and medical history, plasma levels of tau phosphorylated at threonine 217 (pT217), pT181, neurofilament light (NfL), CTRP3, 4, and 14 were examined and compared. Multivariate logistic regression analysis was applied to determine associations of plasma CTPRs with the presence of AD. The correlation analysis was used to explore correlations between plasma CTPRs with scores of Mini\u2010Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living (ADL) scale, and Clinical Dementia Rating Sum of Boxes (CDR\u2010SB), and levels of plasma pT217, pT181, and NfL. Receiver\u2010operating characteristic (ROC) analysis and Delong's test were used to determine the diagnostic power of plasma CTPRs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma levels of CTRP3, 4, and 14 were higher in AD group than those in CN group. After adjusting for conventional risk factors, CTRP3, CTRP4, and CTRP14 were associated with the presence of AD. In AD patients, CTRP3 was negatively correlated with scores of MMSE and MoCA, while positively correlated with ADL score, CDR\u2010SB score, pT217, and pT181; CTRP4 was positively correlated with CDR\u2010SB score, pT181, and NfL; CTRP14 was negatively correlated with MMSE score, while positively correlated with CDR\u2010SB score, pT217, and NfL. An independent addition of CTRP3 and 4 to the basic model combining age, sex, years of education,\n                      <jats:italic>APOE4<\/jats:italic>\n                      status, BMI, TG, and HDL\u2010C led to a significant improvement in diagnostic power for AD, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All the findings preliminarily uncovered associations between plasma CTRPs and AD and suggested the potential of CTRPs as a blood\u2010derived biomarker for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14606","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T05:20:37Z","timestamp":1707456037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between plasma\n                    <scp>CTRPs<\/scp>\n                    with cognitive impairment and neurodegeneration of Alzheimer's disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Xiao","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Neurology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"},{"name":"Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"},{"name":"Department of Neurology Yunyang County People's Hospital  Chongqing 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