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The detailed mechanisms of invasion are not yet clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We explored the role of PBK phosphorylation in the proliferation and invasion of prolactinomas and its possible mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We report that PBK directly binds to and is phosphorylated at Thr9 by cyclin\u2010dependent kinase 5 (CDK5), which promotes GH3 cell EMT progression and proliferation. Phosphorylation of PBK at Thr9 (pPBK\u2010T9) by CDK5 enhances the stability of PBK. p38 is one of the downstream targets of PBK, and its phosphorylation is reduced as pPBK\u2010T9 increases in\u00a0vivo and in\u00a0vitro. Furthermore, we found that pPBK\u2010T9 is highly expressed in invasive PitNETs and was significantly correlated with invasion by univariate and multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Phosphorylation of PBK at Thr9 by CDK5 promotes cell proliferation and EMT progression in prolactinomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14629","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T06:09:31Z","timestamp":1708063771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phosphorylation of\n                    <scp>PBK<\/scp>\n                    at Thr9 by\n                    <scp>CDK5<\/scp>\n                    correlates with invasion of prolactinomas"],"prefix":"10.1111","volume":"30","author":[{"given":"Qiuyue","family":"Fang","sequence":"first","affiliation":[{"name":"Beijing Neurosurgical Institute Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxiaofeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Nie","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing 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