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There is evidence that boosting phasic GABA signaling with zolpidem during the repair phase improves stroke recovery by enhancing neural plasticity; however, as a non\u2010benzodiazepine hypnotic, the effects of zolpidem on post\u2010stroke sleep disorders remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Transient ischemic stroke in male rats was induced with a 30\u2010minute middle cerebral artery occlusion. Zolpidem or vehicle was intraperitoneally delivered once daily from 2 to 7\u2009days after the stroke, and the electroencephalogram and electromyogram were recorded simultaneously. At 24\u2009h after ischemia, c\u2010Fos immunostaining was used to assess the effect of transient ischemic stroke and acute zolpidem treatment on neuronal activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In addition to the effects on reducing brain damage and mitigating behavioral deficits, repeated zolpidem treatment during the subacute phase of stroke quickly ameliorated circadian rhythm disruption, alleviated sleep fragmentation, and increased sleep depth in ischemic rats. Immunohistochemical staining showed that in contrast to robust activation in para\u2010infarct and some remote areas by 24\u2009h after the onset of focal ischemia, the activity of the ipsilateral suprachiasmatic nucleus, the biological rhythm center, was strongly suppressed. A single dose of zolpidem significantly upregulated c\u2010Fos expression in the ipsilateral suprachiasmatic nucleus to levels comparable to the contralateral side.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Stroke leads to suprachiasmatic nucleus dysfunction. Zolpidem restores suprachiasmatic nucleus activity and effectively alleviates post\u2010stroke sleep disturbances, indicating its potential to promote stroke recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14637","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:27:01Z","timestamp":1708496821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery"],"prefix":"10.1111","volume":"30","author":[{"given":"Zhi\u2010Gang","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Institute for Basic Research on Aging and Medicine, School of Basic Medical Sciences Fudan University  Shanghai China"},{"name":"Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of 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