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Given Annexin A6 (ANXA6)'s potential in promoting axon branching and repairing cell membranes, the study aimed to explore ANXA6's potential in alleviating AIS\u2010induced neurological dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A mouse middle cerebral artery occlusion model was established. Brain and plasma ANXA6 levels were detected at different timepoints post ischemia\/reperfusion (I\/R). We overexpressed and down\u2010regulated brain ANXA6 and evaluated infarction volume, neurological function, and synaptic plasticity\u2010related proteins post I\/R. Plasma ANXA6 levels were measured in patients with AIS and healthy controls, investigating ANXA6 expression's clinical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Brain ANXA6 levels initially decreased, gradually returning to normal post I\/R; plasma ANXA6 levels showed an opposite trend. ANXA6 overexpression significantly decreased the modified neurological severity score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0109) 1\u2009day post I\/R and the infarction area at 1\u2009day (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008) and 7\u2009day (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0013) post I\/R, and vice versa. ANXA6 positively influenced synaptic plasticity, upregulating synaptophysin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), myelin basic protein (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010), neuroligin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.078), and tropomyosin\u2010related kinase B (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.150). Plasma ANXA6 levels were higher in patients with AIS (1.969 [1.228\u20133.086]) compared to healthy controls (1.249 [0.757\u20132.226]) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), that served as an independent risk factor for poor AIS outcomes (2.120 [1.563\u20133.023],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is the first to suggest that ANXA6 enhances synaptic plasticity and protects against transient cerebral ischemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14639","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:26:54Z","timestamp":1708496814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Annexin\n                    <scp>A6<\/scp>\n                    mitigates neurological deficit in ischemia\/reperfusion injury by promoting synaptic plasticity"],"prefix":"10.1111","volume":"30","author":[{"given":"Yilin","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangmin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziping","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfen","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-8974","authenticated-orcid":false,"given":"Yumin","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"},{"name":"Beijing Institute for Brain Disorders  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004597"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.1420"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032810"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.12.020"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03963-7"},{"issue":"3","key":"e_1_2_12_7_1","first-page":"640","article-title":"Alterations of annexin expression in pathological neuronal and glial reactions. 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