{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:56:09Z","timestamp":1792176969318,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2022YFC3501005"],"award-info":[{"award-number":["2022YFC3501005"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82027802"],"award-info":[{"award-number":["82027802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intermittent hypoxia (IH) is emerging as a cost\u2010effective nonpharmacological method for vital organ protection. We aimed to assess the effects of a short\u2010term moderate intermittent hypoxia preconditioning protocol (four cycles of 13% hypoxia lasting for 10\u2009min with 5\u2010min normoxia intervals) on acute hypoxic injury induced by sustained hypoxic exposure (oxygen concentration of 11.8% for 6\u2009h).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred healthy volunteers were recruited and randomized to the IH group and the control group to receive IH or sham\u2010IH preconditioning for 5\u2009days, respectively, and then were sent to a hypoxic chamber for simulated acute high\u2010altitude exposure (4500\u2009m).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall incidence of acute mountain sickness was 27% (27\/100), with 14% (7\/50) in the IH group and 40% (20\/50) in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). After 6\u2010h simulated high\u2010altitude exposure, the mean Lake Louise Score was lower in the IH group as compared to controls (1.30\u2009\u00b1\u20091.27 vs. 2.04\u2009\u00b1\u20091.89, <jats:italic>p<\/jats:italic>\u2009=\u20090.024). Mean peripheral oxygen saturations (SpO<jats:sub>2<\/jats:sub>) and intracranial pressure (ICP) measures after acute hypoxic exposure exhibited significant differences, with the IH group showing significantly greater SpO<jats:sub>2<\/jats:sub> values (85.47\u2009\u00b1\u20095.14 vs. 83.10\u2009\u00b1\u20095.15%, <jats:italic>p<\/jats:italic>\u2009=\u20090.026) and lower ICP levels than the control group (115.59\u2009\u00b1\u200932.15 vs. 130.36\u2009\u00b1\u200933.83\u2009mmH<jats:sub>2<\/jats:sub>O, <jats:italic>p<\/jats:italic>\u2009=\u20090.028). IH preconditioning also showed greater effects on serum protein gene product 9.5 (3.89 vs. 29.16\u2009pg\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.048) and C\u2010reactive protein (\u22120.28 vs. 0.41\u2009mg\/L; <jats:italic>p<\/jats:italic>\u2009=\u20090.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The short\u2010term moderate IH improved the tolerance to hypoxia and exerted protection against acute hypoxic injury induced by exposure to sustained normobaric hypoxia, which provided a novel method and randomized controlled trial evidence to develop treatments for hypoxia\u2010related disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14662","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T09:35:16Z","timestamp":1710322516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intermittent hypoxia preconditioning can attenuate acute hypoxic injury after a sustained normobaric hypoxic exposure: A randomized clinical trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-3894","authenticated-orcid":false,"given":"Yuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-3170","authenticated-orcid":false,"given":"Qihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing 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