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The role of epidermal growth factor receptor 1 (ERBB1) in ICH was elucidated in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ICH model was constructed by injecting autologous arterial blood into the right basal ganglia. The protein level of ERBB1 was detected by western blot analysis. To up\u2010 and downregulation of ERBB1 in rats, intraventricular injection of a lentivirus overexpression vector of ERBB1 and AG1478 (a specific inhibitor of ERBB1) was used. The cell apoptosis, neuronal loss, and pro\u2010inflammatory cytokines were assessed by TUNEL, Nissl staining, and ELISA. Meanwhile, behavioral cognitive impairment of ICH rats was evaluated after ERBB1\u2010targeted interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ERBB1 increased significantly in brain tissue of ICH rats. Overexpression of ERBB1 remarkably reduced cell apoptosis and neuronal loss induced by ICH, as well as pro\u2010inflammatory cytokines and oxidative stress. Meanwhile, the behavioral and cognitive impairment of ICH rats were alleviated after upregulation of ERBB1; however, the secondary brain injury (SBI) was aggravated by AG1478 treatment. Furthermore, the upregulation of PLC\u2010\u03b3 and PKC in ICH rats was reversed by AG1478 treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ERBB1 can improve SBI and has a neuroprotective effect in experimental ICH rats via PLC\u2010\u03b3\/PKC pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14679","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T07:37:27Z","timestamp":1711438647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>ERBB1<\/scp> alleviates secondary brain injury induced by experimental intracerebral hemorrhage in rats by modulating neuronal death via <scp>PLC<\/scp>\u2010\u03b3\/<scp>PKC<\/scp> pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Bing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery &amp; Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow University  Suzhou Jiangsu Province China"},{"name":"Department of Neurosurgery, Yancheng City No. 1 People's Hospital, Yancheng First Hospital Affiliated Hospital of Nanjing University Medical School  Yancheng Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery &amp; 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