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The primary motor cortex and subthalamic nucleus were stimulated sequentially with ccPAS. Unlike the active ccPAS group, one wing of coil was tilted to form a 90\u00b0 angle with scalp of stimulation locations for the sham ccPAS group. Magnetic resonance imaging, functional reach test (FRT), timed up and go (TUG) test, and limit of stability (LOS) test were performed, and correlation between them was also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three participants in the sham ccPAS group were excluded because of poor quality of NIfTI images. The active group had strengthened hyperdirect pathway, increased functional connectivity (FC) between orbital part of frontal cortex and bilateral precuneus, and decreased FC among basal ganglia (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Regional network properties of triangular and orbital parts of IFG, middle cingulate cortex, and hippocampus increased. The active group performed better in FRT and LOS (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). FRT positively correlated with FC of the hyperdirect pathway (<jats:italic>r<\/jats:italic>\u2009=\u20090.439, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and FCs between orbital part of frontal cortex and bilateral precuneus (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ccPAS enhanced balance performance by promotion\u2010like plasticity mechanisms through the hyperdirect pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14710","type":"journal-article","created":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T20:58:52Z","timestamp":1713128332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The promotion\u2010like effect of the M1\u2010STN hyperdirect pathway induced by ccPAS enhanced balance performances: From the perspective of brain connectivity"],"prefix":"10.1111","volume":"30","author":[{"given":"Yu\u2010Lin","family":"Li","sequence":"first","affiliation":[{"name":"Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of Education  Shanghai China"},{"name":"Department of Rehabilitation Medicine, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010Yun","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  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