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However, whether nociceptive stimulation affects body temperature and its mechanism remains poorly studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used capsaicin, formalin, and surgery to induce acute nociceptive stimulation and monitored rectal temperature. Optical fiber recording, chemical genetics, confocal imaging, and pharmacology assays were employed to confirm the role and interaction of POA astrocytes and extracellular adenosine. Immunofluorescence was utilized for further validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute nociception could activate POA astrocytes and induce a decrease in body temperature. Manipulation of astrocytes allowed bidirectional control of body temperature. Furthermore, acute nociception and astrocyte activation led to increased extracellular adenosine concentration within the POA. Activation of adenosine A1 or A2A receptors contributed to decreased body temperature, while inhibition of these receptors mitigated the thermo\u2010lowering effect of astrocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results elucidate the interplay between acute nociception and thermoregulation, specifically highlighting POA astrocyte activation. This enriches our understanding of physiological responses to painful stimuli and contributes to the analysis of the anatomical basis involved in the process.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14726","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T04:34:31Z","timestamp":1715142871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Astrocytes in preoptic area regulate acute nociception\u2010induced hypothermia through adenosine receptors"],"prefix":"10.1111","volume":"30","author":[{"given":"Junke","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital Wuhan University  Wuhan 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